Unique Topical Treatment for UV-Induced Skin Cancer

针对紫外线诱发的皮肤癌的独特局部治疗

• 批准号: 6693453
• 负责人: BAKUL M BHATT
• 金额: $ 15.23万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-09 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693453
• 关键词: apoptosis; caffeine; chemical property; chemoprevention; disease /disorder model; drug delivery systems; drug design /synthesis /production; hairless mouse; laboratory mouse; neoplasm /cancer pharmacology; physical property; polyvinyls; radiation carcinogenesis; radiation related neoplasm /cancer; skin neoplasms; spectrometry; surface coating; ultraviolet radiation

DESCRIPTION (provided by applicant): The goal of this project is to develop a polymer-based vehicle for the topical delivery of caffeine to inhibit UV-induced skin cancer. Despite increased use of sun screen, skin cancer rates continue to rise. Recently, caffeine has been shown to inhibit carcinogenesis in murine models of UV-induced skin tumor formation. The polymer-based delivery system described in this proposal seeks to improve the efficacy and convenience of topically applied caffeine for this application. To achieve this goal, the following Specific Aims will be pursued: Aim 1. Formulate a Polymer-based Topical Delivery System Containing Caffeine Aim 2. Evaluate the Effect of Caffeine Delivered from the Polymer-based Vehicle on Ultraviolet Light-induced Skin Cancer Using a Mouse Model.

描述（由申请人提供）：本项目的目标是开发一种基于聚合物的载体，用于局部递送咖啡因以抑制紫外线诱导的皮肤癌。尽管人们越来越多地使用防晒霜，但皮肤癌的发病率仍在上升。最近，咖啡因已被证明可以抑制紫外线诱导的皮肤肿瘤形成的小鼠模型中的致癌作用。在该提案中描述的基于聚合物的递送系统试图改善用于该应用的局部施用的咖啡因的功效和便利性。 为实现这一目标，将追求以下具体目标： 目标1。配制含咖啡因的聚合物基局部给药系统 目标2.评价从基于聚合物的载体递送的咖啡因对 使用小鼠模型的紫外线诱导皮肤癌。