Prevention of Biofilm in Hemodialysis Water Systems

血液透析水系统中生物膜的预防

• 批准号: 6484505
• 负责人: BAKUL M BHATT
• 金额: $ 37.98万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484505
• 关键词: antiinfective agents; antisepsis; biological models; clinical research; disease /disorder prevention /control; disinfectants; hemodialysis; hemolysis; human subject; molecular film; pyrogens; technology /technique development; water quality; water supply

DESCRIPTION (Provided by applicant): Hemodialysis-related infections and adverse patient outcomes continue to be associated with contaminated fluids often arising from biofilm formation in the tubing of hemodialysis systems. Currently available reagents to disinfect fluid delivery lines are either hazardous to humans, unpleasant to work with, environmentally unsafe, or corrosive to expensive hemodialysis equipment at the required contact times. Biomedical Development Corporation is developing a unique disinfectant to improve the quality of water and dialysate circulating through hemodialysis systems. The disinfectant is biocidal against a broad spectrum of organisms and operates as a biofilm reducing agent in clinical water delivery systems. Preliminary studies demonstrate that the disinfectant is an effective antimicrobial, even in the presence of biofilm, is nontoxic, and inexpensive to produce. This study will involve adaptation of the disinfectant for clinical use, and include extensive safety and efficacy testing in preparation for approval and use in hemodialysis fluid delivery systems.

描述（由申请人提供）：血液透析相关感染和 患者不良结局仍与受污染的液体有关 通常由血液透析系统的管道中的生物膜形成引起。 目前可用于消毒流体输送管线的试剂是 对人类有害，工作不愉快，环境不安全，或 在所需的接触时间内对昂贵的血液透析设备具有腐蚀性。 生物医学开发公司正在开发一种独特的消毒剂， 改善血液透析循环用水和透析液的质量 系统.该消毒剂对广谱生物体具有生物杀灭作用， 在临床水输送系统中作为生物膜还原剂。 初步研究表明，该消毒剂是一种有效的 抗菌剂，即使在生物膜的存在下，也是无毒的， 美食的备受本研究将涉及消毒剂的适应性，用于临床 使用，并包括广泛的安全性和有效性测试， 批准并用于血液透析液体输送系统。