Non-Toxic Antimicrobial Rinse for Gingivitis

用于牙龈炎的无毒抗菌冲洗液

• 批准号: 6587414
• 负责人: BAKUL M BHATT
• 金额: $ 34.14万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587414
• 关键词: Non; Toxic; Antimicrobial; Rinse; Gingivitis

DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop Iocide(r), a unique non-toxic, non-staining mouthrinse to treat gingivitis. Antimicrobial mouthrinses are valuable supplements to normal oral hygiene procedures and have demonstrated their ability to control plaque formation and prevent the onset of early periodontal disease. However, currently available antimicrobial rinses are either indicated only for short term use or demonstrate ineffective microbicidal activity. Chlorhexidine is the most effective antimicrobial mouthrinse available, but due to its side effects can only be used in acute settings. Other available animicrobial mouthrinses can be used over longer periods of time but are less effective than chlorhexidine in reducing oral bacteria. The Specific Aims of this grant are to 1) Optimize the Iocide(r) oral rinse formulation for use in the oral cavity, 2) Evaluate the safety profile in animals, and 3) Demonstrate its safety and efficacy in human clinical trials.

描述（由申请人提供）：本提案的总体目标是开发Iocide（r），一种独特的无毒、无染色漱口水，用于治疗牙龈炎。 抗菌漱口水是正常口腔卫生程序的有价值的补充，并已证明其控制牙菌斑形成和预防早期牙周病发作的能力。 然而，目前可用的抗微生物冲洗剂要么仅适用于短期使用，要么表现出无效的杀微生物活性。 洗必泰是最有效的抗菌漱口水，但由于其副作用，只能用于急性环境。其他可用的抗菌漱口水可以使用更长的时间，但在减少口腔细菌方面不如氯己定有效。 该授权的具体目的是1）优化用于口腔的Iocide（r）口腔冲洗剂配方，2）评估动物的安全性，3）证明其在人体临床试验中的安全性和有效性。