Novel Topical Treatment of Eczema

湿疹的新型局部治疗方法

• 批准号: 7157258
• 负责人: BAKUL M BHATT
• 金额: $ 13.46万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157258
• 关键词: clinical research; contact dermatitis; hand; human; skin

DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents 1 of the 4 most common occupationally related diseases, accounting for substantial lost earning potential in otherwise healthy populations. Both irritant and allergic contact dermatitis is characterized by erythema and vesicles, as well as dry skin that demonstrate changes in the biophysical properties of the stratum corneum, especially with respect to the water permeability barrier. Recent research in dermatology has investigated treatments that focus on restoring barrier homeostasis for skin conditions including hypertrophic scars and keloids, inflammatory dermatoses such as atopic dermatitis and psoriasis, disorders of keratinization, and eczema. The goal of this project is to develop a novel topical vehicle to treat contact dermatitis/eczema. The Specific Aims of the Research Plan are to optimize a novel coating formulation to include physiologic lipids, and then evaluate the optimized coatings in a prospective, randomized, double-blind left/right comparative clinical trial involving patients with hand eczema. Hand eczema is the most common occupational skin disease and affects a large population of those of working age. Hand eczema is common in professions such as mechanics, textile workers, hair dressers, and especially healthcare workers. In healthcare personnel, hand dermatitis including redness, dryness, and cracking occurs regularly (18.3%-72.9%) as a consequence to frequent hand washing, antisepsis techniques, and chronic occlusion from gloving. Damaged hands increase the risk of colonization of microorganisms on the skin and deter hand washing, and also provide a route for skin sensitization to natural rubber latex proteins. Notably, a positive correlation between the clinical diagnoses of latex protein allergy with pre-existing hand eczema (82%) has been shown.

描述（由申请人提供）：刺激性和过敏性接触性皮炎影响约10%的成年人，手部湿疹是4种最常见的职业相关疾病之一，导致健康人群的收入潜力大幅下降。刺激性和过敏性接触性皮炎的特征均为红斑和水疱，以及表现出角质层生物物理特性变化的干燥皮肤，尤其是在透水性屏障方面。最近的皮肤病学研究已经调查了专注于恢复皮肤状况的屏障稳态的治疗，所述皮肤状况包括肥厚性瘢痕和瘢痕疙瘩、炎性皮肤病如特应性皮炎和牛皮癣、角质化障碍和湿疹。本项目的目标是开发一种新的局部载体来治疗接触性皮炎/湿疹。研究计划的具体目的是优化一种新型涂层配方，以包含生理脂质，然后在涉及手部湿疹患者的前瞻性、随机、双盲左/右比较临床试验中评价优化的涂层。手部湿疹是最常见的职业性皮肤病，影响了大量的工作年龄人群。手部湿疹常见于机械师、纺织工人、理发师等职业，尤其是医护人员。在医护人员中，由于频繁洗手、消毒技术和戴手套造成的慢性闭塞，经常发生手部皮炎，包括发红、干燥和开裂（18.3%-72.9%）。受损的手增加了微生物在皮肤上定植的风险并阻止洗手，并且还提供了皮肤对天然橡胶胶乳蛋白致敏的途径。值得注意的是，乳胶蛋白过敏的临床诊断与先前存在的手部湿疹（82%）之间存在正相关性。