Detection of Coronary Stenoses Using T2-Weighted MRI

使用 T2 加权 MRI 检测冠状动脉狭窄

• 批准号: 6680637
• 负责人: Debiao Li
• 金额: $ 35.68万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-05 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6680637
• 关键词: adenosine; artery stenosis; bioimaging /biomedical imaging; blood flow measurement; blood volume; cardiovascular imaging /visualization; cardiovascular pharmacology; coronary artery; disease /disorder model; dogs; magnetic resonance imaging; oxygen consumption; perfusion; respiratory oxygenation; technology /technique development; three dimensional imaging /topography

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the prognosis of patients with coronary artery disease. We propose to use magnetic resonance imaging (MRI) to detect the presence of clinically significant coronary artery stenoses by assessing the myocardial T2 changes using a T2-weighted technique. The long term goal is to identify those patients at risk of ischemic heart disease who might benefit from vascular interventions such as percutaneous transluminal angioplasty or bypass graft. In the proposed project, a well-controlled animal model (dog) will be used. Various levels of coronary artery stenoses will be created. The studies will be performed on a state-of-the-art 3-Tesla imaging system to improve the sensitivity of the test. Compared to the conventional method of myocardial perfusion evaluation using first-pass contrast-enhanced technique, the proposed method has the advantage of potentially not requiring pharmacological stress test, and/or better spatial resolution and coverage. The specific aims of the proposed project are: Aim 1: To develop a T2-prepared three-dimensional true fast imaging with steady state precession technique for T2 measurement in the heart and to validate MR blood volume fraction measurement on phantom. Aim 2: To verify that regional myocardial T2 difference following direct adenosine injection into the coronary artery is greater at 3.0 T than that at 1.5 T. Aim 3: To test whether territory supplied by functionally significant coronary artery stenoses can be detected using T2-weighted MR imaging under resting conditions. Aim 4: To test whether MR T2-weighted imaging can detect a 2-fold regional difference in blood flow reserve under pharmacologic stress. Positive results from this project will warrant clinical studies in patients to evaluate the role of T2-weighted MR imaging in detecting functionally significant coronary artery disease.

描述（由申请人提供）： 该提案的广泛长期目标是改善冠状动脉疾病患者的预后。我们建议使用磁共振成像（MRI）通过使用T2加权技术评估心肌T2的变化来检测临床上显着的冠状动脉促促性损伤的存在。长期目标是确定那些有缺血性心脏病风险的患者，他们可能会受益于诸如经皮易流动性血管成形术或旁路移植物等血管干预措施。在拟议的项目中，将使用一个控制良好的动物模型（DOG）。将创建各种水平的冠状动脉狭窄。这些研究将在最先进的3-TESLA成像系统上进行，以提高测试的敏感性。与使用第一级对比增强技术的心肌灌注评估的常规方法相比，所提出的方法具有潜在的不需要药理压力测试和/或更好的空间分辨率和覆盖范围的优势。拟议项目的具体目的是：目标1：使用稳态进动技术开发出T2的三维真实成像，用于心脏中的T2测量，并验证Phantom上的MR血量分数测量。目的2：要验证直接注射腺苷动脉后的区域心肌T2差异3.0 T大于1.5 t。目标3：测试是否可以在休息条件下使用T2-tewightighted MR成像检测到功能上重要的冠状动脉狭窄。 AIM 4：测试MR T2加权成像是否可以在药理应力下检测到血流储备的2倍区域差异。该项目的积极结果将保证在患者中进行临床研究，以评估T2加权MR成像在检测功能意义的冠状动脉疾病中的作用。