Detection of Coronary Stenoses Using T2-Weighted MRI

使用 T2 加权 MRI 检测冠状动脉狭窄

• 批准号: 6680637
• 负责人: Debiao Li
• 金额: $ 35.68万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-05 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6680637
• 关键词: adenosine; artery stenosis; bioimaging /biomedical imaging; blood flow measurement; blood volume; cardiovascular imaging /visualization; cardiovascular pharmacology; coronary artery; disease /disorder model; dogs; magnetic resonance imaging; oxygen consumption; perfusion; respiratory oxygenation; technology /technique development; three dimensional imaging /topography

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the prognosis of patients with coronary artery disease. We propose to use magnetic resonance imaging (MRI) to detect the presence of clinically significant coronary artery stenoses by assessing the myocardial T2 changes using a T2-weighted technique. The long term goal is to identify those patients at risk of ischemic heart disease who might benefit from vascular interventions such as percutaneous transluminal angioplasty or bypass graft. In the proposed project, a well-controlled animal model (dog) will be used. Various levels of coronary artery stenoses will be created. The studies will be performed on a state-of-the-art 3-Tesla imaging system to improve the sensitivity of the test. Compared to the conventional method of myocardial perfusion evaluation using first-pass contrast-enhanced technique, the proposed method has the advantage of potentially not requiring pharmacological stress test, and/or better spatial resolution and coverage. The specific aims of the proposed project are: Aim 1: To develop a T2-prepared three-dimensional true fast imaging with steady state precession technique for T2 measurement in the heart and to validate MR blood volume fraction measurement on phantom. Aim 2: To verify that regional myocardial T2 difference following direct adenosine injection into the coronary artery is greater at 3.0 T than that at 1.5 T. Aim 3: To test whether territory supplied by functionally significant coronary artery stenoses can be detected using T2-weighted MR imaging under resting conditions. Aim 4: To test whether MR T2-weighted imaging can detect a 2-fold regional difference in blood flow reserve under pharmacologic stress. Positive results from this project will warrant clinical studies in patients to evaluate the role of T2-weighted MR imaging in detecting functionally significant coronary artery disease.

描述（由申请人提供）： 该提案的广泛、长期目标是改善冠状动脉疾病患者的预后。我们建议使用磁共振成像 (MRI) 通过 T2 加权技术评估心肌 T2 变化来检测是否存在临床上显着的冠状动脉狭窄。长期目标是确定那些有缺血性心脏病风险的患者，他们可能受益于血管干预措施，如经皮腔内血管成形术或旁路移植术。在拟议的项目中，将使用控制良好的动物模型（狗）。将产生不同程度的冠状动脉狭窄。这些研究将在最先进的 3-Tesla 成像系统上进行，以提高测试的灵敏度。与使用首过对比增强技术的心肌灌注评估的传统方法相比，所提出的方法具有潜在不需要药理学负荷测试和/或更好的空间分辨率和覆盖范围的优点。该项目的具体目标是： 目标 1：开发一种 T2 准备的三维真实快速成像，采用稳态进动技术，用于心脏 T2 测量，并验证体模上的 MR 血容量分数测量。目标 2：验证直接向冠状动脉注射腺苷后，3.0 T 时的局部心肌 T2 差异大于 1.5 T 时的差异。 目标 3：测试是否可以在静息条件下使用 T2 加权 MR 成像检测由功能显着的冠状动脉狭窄提供的区域。目标 4：测试 MR T2 加权成像是否可以检测药物应激下血流储备的 2 倍区域差异。该项目的积极结果将保证对患者进行临床研究，以评估 T2 加权 MR 成像在检测功能性显着冠状动脉疾病中的作用。