4Dx Small Animal Scanner for Functional Lung Imaging

用于功能性肺部成像的 4Dx 小动物扫描仪

• 批准号: 9075865
• 负责人: Debiao Li
• 金额: $ 60万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075865
• 关键词: Acute Lung Injury; Adult Respiratory Distress Syndrome; Animals; Asthma; Australia; Detection; Development; Diagnostic radiologic examination; Distal; Environmental Wind; Equipment; Funding; Goals; Health; Image; Infection; Institution; Laboratories; Leadership; Lung; Lung diseases; Maps; Measurement; Measures; Mechanics; Medical center; Modeling; Motion; Patients; Physiology; Pulmonary Emphysema; Pulmonary Fibrosis; Pulmonology; Radiation; Research Personnel; Resistance; Resolution; Respiratory physiology; Scientist; Segmental bronchus structure; Small Animal Imaging Systems; Staging; Technology; Trachea; United States National Institutes of Health; Universities; accurate diagnosis; experience; improved; instrument; lung development; lung imaging; lung injury; public health research; pulmonary function; respiratory; temporal measurement

 DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the detection and treatment of lung disease. Investigators at the Cedars-Sinai Medical Center propose to purchase a 4Dx scanner, which has the unique capacity for measuring regional pulmonary function at an unprecedented level of spatial and temporal resolution. This technology combines wind tunnel technology with advanced X-ray imaging. Detailed measurement of motion allows the calculation of high-resolution regional maps of airflow, lung resistance and compliance at each stage of a breath. It can be used to uniquely obtain quantitative pulmonary functional measures in all airways from the trachea to the distal sub-segmental bronchi of the lung. This technology can be applied to all translational models of lung disease, including acute lung injury, pulmonary fibrosis, asthma, infection, emphysema, radiation-induced lung injury, and lung development. To date this technology has been limited to use in the small animal scanner currently operating in the Laboratory for Dynamic Imaging at Monash University, Australia. We hope to bring this breakthrough technology to Cedars-Sinai Medical Center where multiple NIH-funded projects are conducted in lung disease. Major users of the requested instrument will include highly accomplished scientists across respiratory medicine, pulmonary physiology, mechanics, and development. Extensive technical experience exists in our institution in managing small animal imaging systems. Dr. Fouras, inventor of the 4Dx technology, will be a consultant to provide technical assistance. A comprehensive technical, scientific, administrative, and financial plan is proposed to govern usage of this instrument at our institution. This application had strong support from the institutional leadership. The relevance to public health of research performed on this requested equipment is it will provide quantitative measurements of the lung function for accurate diagnosis and characterization of lung diseases such as emphysema, asthma, lung fibrosis, and acute respiratory distress syndrome, all major health problems in the USA. The long-term goal is to improve patient treatments and evaluate potential therapies.

 描述（由适用提供）：该提案的广泛长期目标是改善对肺部疾病的检测和治疗。 Cedars-Sinai Medical Center的研究人员购买了4DX扫描仪，该扫描仪具有独特的能力，可以在空间和临时分辨率的前所未有的水平下测量区域肺功能。该技术将风洞技术与先进的X射线成像结合在一起。详细的运动测量允许计算呼吸的每个阶段的气流，肺阻力和依从性的高分辨率区域地图。它可用于从气管到肺部远端亚段支气管的所有气道中唯一获得定量的肺功能度量。该技术可以应用于所有翻译的肺部疾病模型，包括急性肺损伤，肺纤维化，哮喘，感染，肺气肿，辐射引起的肺损伤和肺发育。迄今为止，该技术仅限于目前在澳大利亚莫纳什大学（Monash University）的动态成像实验室运行的小型动物扫描仪中使用。我们希望将这项突破性技术带到Cedars-Sinai医疗中心，在那里进行了多个NIH资助的项目。要求的仪器的主要用户将包括呼吸医学，肺部生理学，力学和开发的高度成就的科学家。我们的机构中​​存在丰富的技术经验，用于管理小型动物成像系统。 4DX技术发明者Fouras博士将是提供技术援助的顾问。提出了一项全面的技术，科学，行政和财务计划，以管理我们机构对该工具的使用。该申请得到了机构领导的大力支持。与该要求的设备进行的研究的相关性是，它将提供对肺功能的定量测量，以准确诊断和表征肺部疾病，例如肺气肿，哮喘，肺纤维化和急性呼吸窘迫综合征，以及美国所有主要健康问题。长期目标是改善患者治疗并评估潜在的疗法。