4Dx Small Animal Scanner for Functional Lung Imaging

 描述(由申请人提供)：这项提案的广泛、长期目标是改进肺部疾病的检测和治疗。锡达斯-西奈医学中心的研究人员提议购买一台4DX扫描仪，这种扫描仪具有以前所未有的空间和时间分辨率测量区域肺功能的独特能力。这项技术结合了风洞技术和先进的X射线成像技术。对运动的详细测量可以计算出呼吸每个阶段的气流、肺阻力和顺应性的高分辨率区域地图。它可以唯一地在从气管到肺远端亚段支气管的所有呼吸道中获得定量的肺功能测量。这项技术可以应用于所有肺部疾病的翻译模型，包括急性肺损伤、肺纤维化、哮喘、感染、肺气肿、放射性肺损伤和肺发育。到目前为止，这项技术仅限于用于目前在澳大利亚莫纳什大学动态成像实验室运行的小动物扫描仪。我们希望将这项突破性的技术带到锡达斯-西奈医学中心，在那里，NIH资助的多个肺部疾病项目正在进行。所要求的仪器的主要用户将包括呼吸医学、肺生理学、机械学和发展学领域的高水平科学家。我们机构在管理小动物成像系统方面拥有丰富的技术经验。4DX技术的发明者福拉斯博士将担任顾问，提供技术援助。提出了一项全面的技术、科学、行政和财务计划，以管理该工具在我们机构的使用。这项申请得到了机构领导层的大力支持。在这台所需设备上进行的研究与公共卫生的相关性在于，它将提供肺功能的定量测量，以准确诊断和表征肺病，如肺气肿、哮喘、肺纤维化和急性呼吸窘迫综合征，这些都是美国的主要健康问题。长期目标是改善患者的治疗并评估潜在的治疗方法。

 DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the detection and treatment of lung disease. Investigators at the Cedars-Sinai Medical Center propose to purchase a 4Dx scanner, which has the unique capacity for measuring regional pulmonary function at an unprecedented level of spatial and temporal resolution. This technology combines wind tunnel technology with advanced X-ray imaging. Detailed measurement of motion allows the calculation of high-resolution regional maps of airflow, lung resistance and compliance at each stage of a breath. It can be used to uniquely obtain quantitative pulmonary functional measures in all airways from the trachea to the distal sub-segmental bronchi of the lung. This technology can be applied to all translational models of lung disease, including acute lung injury, pulmonary fibrosis, asthma, infection, emphysema, radiation-induced lung injury, and lung development. To date this technology has been limited to use in the small animal scanner currently operating in the Laboratory for Dynamic Imaging at Monash University, Australia. We hope to bring this breakthrough technology to Cedars-Sinai Medical Center where multiple NIH-funded projects are conducted in lung disease. Major users of the requested instrument will include highly accomplished scientists across respiratory medicine, pulmonary physiology, mechanics, and development. Extensive technical experience exists in our institution in managing small animal imaging systems. Dr. Fouras, inventor of the 4Dx technology, will be a consultant to provide technical assistance. A comprehensive technical, scientific, administrative, and financial plan is proposed to govern usage of this instrument at our institution. This application had strong support from the institutional leadership. The relevance to public health of research performed on this requested equipment is it will provide quantitative measurements of the lung function for accurate diagnosis and characterization of lung diseases such as emphysema, asthma, lung fibrosis, and acute respiratory distress syndrome, all major health problems in the USA. The long-term goal is to improve patient treatments and evaluate potential therapies.