Flow Sensitive SSFP for Non-Contrast MRA and Vessel Wall Imaging
用于非对比 MRA 和血管壁成像的流量敏感 SSFP
基本信息
- 批准号:7644221
- 负责人:
- 金额:$ 36.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-04-20 至 2013-03-31
- 项目状态:已结题
- 来源:
- 关键词:ArteriesBloodCardiacCause of DeathClinicalContrast MediaDeglutitionDependenceDetectionDevelopmentDiastoleDiseaseDistalEvaluationFibrosisGadoliniumImageImageryImaging TechniquesKidneyKidney FailureMagnetic ResonanceMagnetic Resonance ImagingMethodsMorphologic artifactsMotionNoisePatientsPeripheralPeripheral arterial diseasePhasePreparationResearchRiskSchemeSignal TransductionSliceSpeedStenosisSystoleTechniquesThree-Dimensional ImageTimeTissuesTrainingUnited StatesValidationVeinsVenousartery stenosisbasedata acquisitionimprovedoutcome forecastpublic health relevancerespiratory
项目摘要
DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the prognosis of patients with arterial disease, one of the leading causes of death in the United States. Contrast-enhanced imaging is the clinically accepted conventional method for MRA. However, patients with renal insufficiency who receive gadolinium- based agents are at risk for developing a debilitating and a potentially fatal disease known as nephrogenic systemic fibrosis. The purpose of the proposed project is to develop a new non-contrast-enhanced MRA technique. Two sets of ECG-triggered, cardiac phase-resolved 3D images will be acquired with and without flow sensitized dephasing (FSD) preparation, respectively. In systole, steady state free precession (SSFP) imaging generates bright blood signals for both arteries and veins, independent of flow, while images acquired with FSD preparation show black blood arteries and bright blood veins because FSD preparation causes dramatic signal loss to fast flowing arterial blood but has little effect on slow flowing venous blood and background tissue. Subtraction of the two image sets will show arteries only. The "black-blood" images can also be used for arterial wall evaluation to quantify plaque burden. Therefore, this technique has the potential for simultaneous MRA and arterial wall imaging of the entire body. Specific aims of the project are: (1) To develop the cardiac phase-resolved, FSD-prepared, self-gated 3D SSFP technique for simultaneous MRA and arterial wall imaging. Four tasks will be performed: (a) A self-gating method will be developed to eliminate potential image artifacts due to motion (e.g., swallowing during carotid MRA and respiratory motion for renal MRA). (b) SSFP will be improved for consistent bright blood MRA in the presence of flow. (c) FSD preparation and data acquisition schemes will be optimized to maximize contrast to noise ratio between arterial blood and background/vein for MRA and vessel wall imaging in carotid, renal, and peripheral arteries. (d) k-t parallel imaging will be optimized to improve the speed of cardiac phase-resolved MRA and vessel wall imaging. (2) To verify that the non-contrast MRA and vessel wall imaging technique can accurately depict artery stenoses and quantify plaque burden in patients. Three groups of patients with carotid, renal, and peripheral artery disease, respectively, will be studied. Contrast-enhanced MRA and single-slice turbo spin echo techniques will be used as the reference methods for MRA and wall imaging, respectively. The end point of the project is the development and initial clinical validation of a new non-contrast- enhanced MRA approach capable of simultaneous MRA and arterial wall imaging of the entire body. PUBLIC HEALTH RELEVANCE: The overall objective of this project is to develop a non-contrast-enhanced magnetic resonance imaging technique to detect artery disease in patients with renal insufficiency.
描述(由申请人提供):该提案的广泛长期目标是改善动脉疾病患者的预后,这是美国的主要死亡原因之一。对比增强成像是MRA临床接受的常规方法。然而,接受基于gadolinium的药物的肾功能不全的患者面临着一种衰弱的风险和可能致命的疾病,称为肾病全身性纤维化。拟议项目的目的是开发一种新的非对抗增强的MRA技术。将分别以有或没有流动敏化的Dephasing(FSD)制备,将获取两组ECG触发的心脏相分辨3D图像。在收缩期,无稳态进动(SSFP)成像为动脉和静脉而独立于流动产生明亮的血液信号,而用FSD制备获取的图像显示出黑血动动脉和明亮的血脉,因为FSD制剂会导致急剧信号损失对快速流动的动脉流失,但对流动的流血量很小,对流动的血液和背景组织的影响很小。两个图像集的减法仅显示动脉。 “黑血”图像也可以用于动脉壁评估以量化牙菌斑负担。因此,该技术具有同时对整个身体进行MRA和动脉壁成像的潜力。该项目的具体目的是:(1)开发用于同时MRA和动脉壁成像的心脏相分辨,预先准备的,自系统的3D SSFP技术。将执行四个任务:(a)将开发一种自门的方法,以消除运动引起的潜在图像伪像(例如,在颈动脉MRA期间吞咽和肾脏MRA的呼吸运动)。 (b)在流动存在下,将改善SSFP的一致性明亮血液MRA。 (c)将优化FSD的制备和数据采集方案,以最大程度地与颈动脉,肾脏和外围动脉中的动脉血液与背景/静脉之间的噪声比对比度。 (d)K-T并行成像将被优化,以提高心脏相位分辨MRA和容器壁成像的速度。 (2)验证非对比度MRA和血管壁成像技术可以准确描绘动脉狭窄并量化患者的牙菌斑负担。将研究三组颈动脉,肾脏和周围动脉疾病的患者。对比度增强的MRA和单板涡轮自旋回波技术将分别用作MRA和壁成像的参考方法。该项目的终点是一种能够同时对整个身体进行MRA和动脉壁成像的新的非对比度增强MRA方法的开发和初始临床验证。公共卫生相关性:该项目的总体目的是开发一种非对抗增强的磁共振成像技术,以检测肾脏不足患者的动脉疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Debiao Li其他文献
Debiao Li的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Debiao Li', 18)}}的其他基金
Predicting Pancreatic Ductal Adenocarcinoma (PDAC) Through Artificial Intelligence Analysis of Pre-Diagnostic CT Images
通过诊断前 CT 图像的人工智能分析预测胰腺导管腺癌 (PDAC)
- 批准号:
10475648 - 财政年份:2021
- 资助金额:
$ 36.4万 - 项目类别:
Predicting Pancreatic Ductal Adenocarcinoma (PDAC) Through Artificial Intelligence Analysis of Pre-Diagnostic CT Images
通过诊断前 CT 图像的人工智能分析预测胰腺导管腺癌 (PDAC)
- 批准号:
10693185 - 财政年份:2021
- 资助金额:
$ 36.4万 - 项目类别:
An Accurate Non-Contrast-Enhanced Cardiac MRI Method for Imaging Chronic Myocardial Infarctions: Technical Developments to Rapid Clinical Validation
用于慢性心肌梗塞成像的准确非增强心脏 MRI 方法:快速临床验证的技术发展
- 批准号:
9899302 - 财政年份:2017
- 资助金额:
$ 36.4万 - 项目类别:
4Dx Small Animal Scanner for Functional Lung Imaging
用于功能性肺部成像的 4Dx 小动物扫描仪
- 批准号:
9075865 - 财政年份:2016
- 资助金额:
$ 36.4万 - 项目类别:
Whole-Heart Myocardial Blood Flow Quantification Using MRI
使用 MRI 定量全心心肌血流量
- 批准号:
9226051 - 财政年份:2015
- 资助金额:
$ 36.4万 - 项目类别:
Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back Pain
定量多参数 MRI 评估干细胞疗法对慢性腰痛的效果
- 批准号:
10689204 - 财政年份:2014
- 资助金额:
$ 36.4万 - 项目类别:
Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back Pain
定量多参数 MRI 评估干细胞疗法对慢性腰痛的效果
- 批准号:
10454354 - 财政年份:2014
- 资助金额:
$ 36.4万 - 项目类别:
3D MRI Characterization of High-Risk Carotid Artery Plaques without Contrast Media
无需造影剂的高风险颈动脉斑块的 3D MRI 表征
- 批准号:
8973293 - 财政年份:2009
- 资助金额:
$ 36.4万 - 项目类别:
3D MRI Characterization of High-Risk Carotid Artery Plaques without Contrast Media
无需造影剂的高风险颈动脉斑块的 3D MRI 表征
- 批准号:
9300995 - 财政年份:2009
- 资助金额:
$ 36.4万 - 项目类别:
相似国自然基金
基于AT2/ACE2/Ang(1-7)/MAS轴调控心脏-血管-血液系统性重构演变规律研究心衰气虚血瘀证及其益气通脉活血化瘀治法生物学基础
- 批准号:82305216
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
心外膜脂肪经Adipsin/Dusp26参与射血分数保留心力衰竭心脏重塑的机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
心外膜脂肪经Adipsin/Dusp26参与射血分数保留心力衰竭心脏重塑的机制研究
- 批准号:82270406
- 批准年份:2022
- 资助金额:52.00 万元
- 项目类别:面上项目
11C-N-CH3-Dopamine PET/MRI心脏神经显像对射血分数保留的心衰的实验研究
- 批准号:82171969
- 批准年份:2021
- 资助金额:56 万元
- 项目类别:面上项目
基于当代射血分数降低的心力衰竭患者心脏性猝死风险预测模型的建立和验证
- 批准号:82100404
- 批准年份:2021
- 资助金额:24.00 万元
- 项目类别:青年科学基金项目
相似海外基金
Potassium channels and uteroplacental vessels function in pregnant long QT type 1 women
怀孕长 QT 1 型女性的钾通道和子宫胎盘血管功能
- 批准号:
10665263 - 财政年份:2023
- 资助金额:
$ 36.4万 - 项目类别:
Temporospatial Single-Cell Characterization of Angiogenesis and Myocardial Regeneration in Small and Large Mammals
小型和大型哺乳动物血管生成和心肌再生的时空单细胞表征
- 批准号:
10751870 - 财政年份:2023
- 资助金额:
$ 36.4万 - 项目类别:
Uncertainty aware virtual treatment planning for peripheral pulmonary artery stenosis
外周肺动脉狭窄的不确定性虚拟治疗计划
- 批准号:
10734008 - 财政年份:2023
- 资助金额:
$ 36.4万 - 项目类别:
Catheter-injectable system for local drug delivery after myocardial infarct
用于心肌梗死后局部给药的导管注射系统
- 批准号:
10722614 - 财政年份:2023
- 资助金额:
$ 36.4万 - 项目类别:
Multi-omic signatures of gut dysbiosis and cardiovascular comorbidities associated with HIV infection
与 HIV 感染相关的肠道菌群失调和心血管合并症的多组学特征
- 批准号:
10762411 - 财政年份:2023
- 资助金额:
$ 36.4万 - 项目类别: