The Effects of Jumping on Growing Bones
跳跃对骨骼生长的影响
基本信息
- 批准号:6612790
- 负责人:
- 金额:$ 22.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-18 至 2007-06-30
- 项目状态:已结题
- 来源:
- 关键词:bone density bone development bone imaging /visualization /scanning caucasian American clinical research diet disease /disorder prevention /control elementary school exercise femur hip human subject human therapy evaluation longitudinal human study middle childhood (6-11) normal ossification nutrition related tag osteoporosis photon absorptiometry questionnaires spine
项目摘要
Fractures related to osteoporosis continue to grow at an alarming rate, despite advances in bone biology and pharmaceutical treatment. The situation suggests the need for bold, new strategies for both the treatment and the prevention of osteoporosis. To be successful, such strategies must be based in a sound understanding of the relevant biological mechanisms and sufficiently simple and low cost to be applicable on a national scale to a broad segment of the population. Given that: 1) peak bone mass is an important determinant of fracture risk in later life; 2) up to 40 percent of peak bone mass can be influenced by environmental factors such as exercise and diet; and 3) childhood and prepubescence are the most critical time periods for skeletal mineralization, we conducted during the previous funding period what we believe to be the first randomized controlled study investigating the effects of a highly specific jumping program on bone mass in pre-pubertal children. We showed that 7 months of high-impact loading from jumping off two foot boxes was both safe and effective and resulted in 4.5 percent and 3.1 percent (p less than 0.01) increases compared to controls in bone mineral content (BMC) at the hip and spine, respectively. Moreover, after an additional 7 months of detraining, jumpers maintained a 4 percent greater femoral neck BMC (p less than 0.05). After detraining, the group differences at the spine, although positive, were not statistically significant. The exercise program was simple, practical and low cost enough so that it could be incorporated into elementary school physical education curricula. In this competitive renewal, we now propose to build on and extend these findings by determining: 1) if two sequential, 7-month high- impact jumping interventions can be used to increase bone mass even further; 2) if the increases in bone mass are again maintained after detraining; and 3) if the increases in bone mass observed in the subjects studied during the previous funding period continue to be maintained through puberty and into adolescence. As we have done previously, we will measure ground impact forces from jumping in individual subjects both early and late in the intervention, with the advantage now that dual force plates can be used to determine forces in each leg. Given the relatively stable nature of the Corvallis population, we believe that our program represents a valuable and unique resource for the long-term study of exercise effects in the developing skeleton. We also believe our program can serve as a model for exercise-based interventions that might be implemented successfully on regional and even national levels. Thus, if we continue to produce and maintain practically important and structurally significant increases in bone mass at the hip and spine in growing children, we believe we will have taken an important step toward the bold new strategies that are needed if we are to reverse the continued increases in the numbers of age- related fractures.
尽管骨生物学和药物治疗取得了进步,但与骨质疏松症相关的骨折仍在以惊人的速度增长。 这种情况表明需要采取大胆的新策略来治疗和预防骨质疏松症。 为了取得成功,此类策略必须基于对相关生物机制的充分理解,并且足够简单且成本低廉,以便在全国范围内适用于广大人群。 鉴于:1)峰值骨量是晚年骨折风险的重要决定因素; 2) 高达 40% 的峰值骨量会受到运动和饮食等环境因素的影响; 3)儿童期和青春期前是骨骼矿化最关键的时期,我们在上一个资助期间进行了我们认为是第一项随机对照研究,调查高度特异性的跳跃计划对青春期前儿童骨量的影响。 我们证明,从两个脚箱上跳下进行 7 个月的高冲击负荷既安全又有效,与对照组相比,髋部和脊柱的骨矿物质含量 (BMC) 分别增加了 4.5% 和 3.1%(p 小于 0.01)。 此外,在额外 7 个月的停止训练后,跳绳运动员的股骨颈 BMC 保持了 4% 的增长(p 小于 0.05)。 停止训练后,脊柱的组间差异虽然是积极的,但并不具有统计学意义。 该锻炼项目简单实用、成本低廉,可以纳入小学体育课程。 在这次竞争性更新中,我们现在建议通过确定以下内容来建立和扩展这些发现:1)是否可以使用两次连续的、为期 7 个月的高冲击跳跃干预措施来进一步增加骨量; 2) 停训后骨量的增加是否再次维持; 3)在上一个资助期间研究的受试者中观察到的骨量增加是否在整个青春期和青春期继续保持。 正如我们之前所做的那样,我们将在干预的早期和后期测量个体受试者跳跃时的地面冲击力,现在的优点是可以使用双测力板来确定每条腿的力。 鉴于科瓦利斯人口相对稳定的性质,我们相信我们的计划为长期研究运动对骨骼发育的影响提供了宝贵且独特的资源。 我们还相信,我们的计划可以作为基于运动的干预措施的典范,可以在区域甚至国家层面成功实施。 因此,如果我们继续在成长中的儿童中实现和维持具有实际意义和结构意义的髋部和脊柱骨量的增加,我们相信,如果我们要扭转与年龄相关的骨折数量的持续增加,我们将朝着所需的大胆新策略迈出重要一步。
项目成果
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CHRISTINE M SNOW其他文献
CHRISTINE M SNOW的其他文献
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{{ truncateString('CHRISTINE M SNOW', 18)}}的其他基金
HOLOGIC QDR 4500A XRAY BONE DENSITOMETER
HOLOGIC QDR 4500A X 射线骨密度计
- 批准号:
2767274 - 财政年份:1999
- 资助金额:
$ 22.58万 - 项目类别:
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