HOLOGIC QDR 4500A XRAY BONE DENSITOMETER

HOLOGIC QDR 4500A X 射线骨密度计

• 批准号: 2767274
• 负责人: CHRISTINE M SNOW
• 金额: $ 11.51万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2767274
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; bone density; bone imaging /visualization /scanning; clinical biomedical equipment; densitometry; photon absorptiometry

The realization that biomechanics play a central role in understanding the etiology, treatment and prevention of injuries and pathologies of the human musculoskeletal system has led to a burgeoning interest in non-invasive, densitometric methods for assessing the structural competence of skeletal regions at high risk. Dual energy X-ray Absorptiometry (DXA) has proven to be one of the most precise and accurate of these methods, with data from our own and other laboratories demonstrating that DXA provides: 1) strong (r2=0.7 to 0.9) and highly significant associations with both clinical and ex vivo risk for age- related fractures of the hip and spine; and 2) the best available outcome measure for monitoring aging processes and the skeletal responses to interventions such as exercise and the use of osteodynamic agents. In this NCRR Shared Instrumentation Grant application, the Department of Exercise and Sport Science at Oregon State University (OSU) requests funds for the purchase of a new Hologic QDR 4500A Fan Beam X-Ray Bone Densitometer, a state-of-the-art system that provides fast (5-30 sec), fan-beam spine/hip capability in the supine position, with over four times the throughput of the QDR-1000/W system it will replace. The new system will significantly enhance and extend the reach of three NIH-funded research programs involving musculoskeletal biomechanics and tissue engineering: 1) the effects of jumping on growing bones; 2) hip fracture risk prediction by QDR; and 3) alternatives to autografts for cleft palate repair. Perhaps more importantly, this shared instrument will serve as a centerpiece for ongoing and new collaborative research efforts that will lead to an expanded focus of research in musculoskeletal biomechanics at OSU and a number of new NIH grant applications from OSU and Oregon Health Sciences University (OHSU) over the next several years.

认识到生物力学在理解人类肌肉骨骼系统的损伤和病理的病因、治疗和预防中起着核心作用，这导致了对用于评估高风险骨骼区域的结构能力的非侵入性密度测量方法的兴趣日益增长。 双能X射线吸收测定法（DXA）已被证明是这些方法中最精确和准确的方法之一，来自我们自己和其他实验室的数据表明，DXA提供：1）强（r2=0.7至0.9）并且与年龄相关的髋部和脊柱骨折的临床和离体风险高度显着相关;和2）监测衰老过程和骨骼对干预措施（如运动和使用骨动力剂）的反应的最佳可用结果测量。 在此NCRR共享仪器补助金申请中，俄勒冈州州立大学（OSU）的运动和运动科学系要求资金购买新的Hologic QDR 4500 A扇形束X射线骨密度仪，这是一种最先进的系统，可提供快速的骨密度测量。（5-30秒），仰卧位的扇形束脊柱/髋关节功能，其吞吐量是其将取代的QDR-1000/W系统的四倍以上。 新系统将显著增强和扩展NIH资助的三个研究项目的范围，涉及肌肉骨骼生物力学和组织工程：1）跳跃对生长骨骼的影响; 2）通过QDR预测髋部骨折风险; 3）腭裂修复术的自体移植物替代品。 也许更重要的是，这个共享的工具将作为正在进行的和新的合作研究工作的核心，这将导致在OSU的肌肉骨骼生物力学研究的重点扩大，并从OSU和俄勒冈州健康科学大学（OHSU）在未来几年的一些新的NIH拨款申请。