JUMPING EFFECTS ON GROWING BONES

跳跃对骨骼生长的影响

• 批准号: 6055702
• 负责人: CHRISTINE M SNOW
• 金额: $ 11.81万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-18 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6055702
• 关键词: biomechanics; bone density; bone development; clinical research; clinical trials; diet; exercise; femur; hip; human subject; longitudinal human study; middle childhood (6-11); normal ossification; nutrition related tag; osteoporosis; outcomes research; photon absorptiometry; questionnaires; spine

Osteoporotic fractures are increasing at an alarming rate in this country and result in over 13 billion dollars in health costs annually. Peak bone mass, that is, an individual s maximum bone mass at the completion of skeletal acquisition, is an important determinant Of fracture risk. Bone mass during adult life reflects the amount acquired during growth minus that which is subsequently lost. Thus, maximizing peak bone mass may provide an effective strategy toward preventing osteopenia and osteoporosis. It is postulated that increasing bone mass by 3-5 percent would reduce fracture risk by 20-30 percent. Our data in collegiate female gymnasts demonstrate hip and a spine bone mineral density values of up to 40 percent above normal age-matched controls and above elite runners, despite menstrual irregularities. Further, we have observed the dynamic response of bone to high impact forces in gymnasts over the training season as bone increases 2-5 percent. We plan a randomized, controlled exercise intervention to evaluate the effect of high impact loading as a means to increase bone mass during development and will determine bone mass accrual and bone geometry at the lumbar spine and proximal femur in pre-pubescent girls and boys. Further, we propose to evaluate the bone response from withdrawal of the stimulus over 6 months. Two hundred pre-pubescent children will be recruited during two separate years and randomly assigned to a jumping or a stretching group. The jumping group will perform double leg jumps and th stretching group will act as a control. Outcome variables include bone density (BMD) at the spine and hip, estimated bone volumetric density at the spine, and cross-sectional geometry of the femoral neck and diaphysis. Our proposal specifically addresses objectives related to physical activity and exercise that are outlined in the RFA. Implementing a specific bone loading program during childhood will potentially allow the bone to increase both its mass and mineralization at an earlier age and therefore provide a lager foundation of mineralization for further growth throughout adolescence until skeletal maturity is reached. Our findings are expected to provide a basis for the design of strategies to build bone during growth and thereby reduce osteoporotic fractures.

骨质疏松性骨折在这一领域正以惊人的速度增加 每年造成超过 130 亿美元的医疗费用。 峰值骨量，即个体在某一时刻的最大骨量 骨骼获得的完成，是一个重要的决定因素 骨折风险。 成年期间的骨量反映了获得的量 增长期间减去随后损失的部分。 因此，最大化 峰值骨量可能提供有效的预防策略 骨质减少和骨质疏松症。 据推测，增加骨量 3-5% 将使骨折风险降低 20-30%。 我们的数据 大学女子体操运动员展示臀部和脊柱骨矿物质 密度值比正常年龄匹配对照高出 40%， 尽管月经不规律，但仍高于精英跑步者。 进一步，我们有 观察体操运动员骨骼对高冲击力的动态反应 在整个训练赛季，骨骼会增加 2-5%。 我们计划一个 随机、受控运动干预来评估效果 高冲击负荷是在发育过程中增加骨量的一种手段 并将确定腰椎处的骨量增长和骨几何形状 青春期前女孩和男孩的脊柱和股骨近端。 此外，我们 建议评估撤回刺激后的骨骼反应 超过6个月。 将招募200名青春期前儿童 在两个不同的年份中，随机分配到跳跃或 伸展组。 跳跃组将进行双腿跳跃和 第一个拉伸组将作为对照组。 结果变量包括 脊柱和髋部的骨密度 (BMD)，估计骨体积 脊柱的密度和股骨颈的横截面几何形状 和骨干。 我们的提案专门解决了相关目标 RFA 中概述的体力活动和锻炼。 在童年时期实施特定的骨负荷计划将 可能使骨骼增加其质量和矿化度 在较早的年龄，因此提供了更大的基础 矿化以促进整个青春期的进一步生长直至骨骼 已达到成熟。 我们的研究结果预计将为 设计在生长过程中构建骨骼的策略，从而减少 骨质疏松性骨折。