Symptom Based Transitions in Addiction in Male Twins

描述：(由申请者提供)申请为期3年的支持，以便对过渡进行二次分析 在药物成瘾方面，使用NIDA资助的哈佛药物研究(HDS)的数据，在 越南时代双胞胎登记处(VETR)的哪些8169名成员(一名大型将军 在军队服役的男性同性双胞胎人口样本 越南时代)通过电话采访了一位结构化的精神病学家 诊断性访谈。采访中涉及的是DSM-III-R终身标准 依赖和滥用5类非法药物和2类合法药物，以及 其他精神障碍。可获得的发病年龄和偏移量 这些数据中的每一种药物类别的成瘾特定症状使它们具有唯一性 适用于我们已有的研究向吸毒成瘾转变的方法 已成功用于酒精症状数据。的孪生结构 数据允许研究遗传因素对发生和发展的影响 过渡到对特定药物上瘾。具体来说，我们将：1)探索 毒品类特定成瘾的病因学及探讨其作用 分类中的遗传因素，使用潜在结构技术，如 潜在类别分析；2)研究两者成瘾的转变 流行病学和遗传框架，使用a)更传统的方法 这取决于药物使用模式(例如，开始、正常和问题使用)，如 以及b)基于人-年成瘾症状的新方法， 开发一种纳入症状补偿的方法；3)研究因素 (包括使用其他物质、精神共病、社交 特征、家族病史)可能促进、加速或抑制 过渡；以及4)尽可能使用以下方法进行交叉研究分析 其他数据来源，特别是越南时代研究(VES)的数据， 国家共病调查(NCS)，国家纵向酒精流行病学 调查(NLAES)，以及酒精中毒遗传学的合作研究 (COGA)，以测试研究结果的可复制性。我们期待我们的 拟议的分析将有助于理解 对特定类型的药物上瘾。最终，我们的研究可能会表明 在特定的药物成瘾的过渡中的某些点可能是 易于采取预防性干预。

DESCRIPTION: (provided by applicant) Support is requested for 3 years to conduct secondary analyses of transitions in drug addiction, using data from the NIDA-funded Harvard Drug Study (HDS), in which 8169 members of the Vietnam Era Twin Registry (VETR) (a large general population sample of male same-sex twins who served in the military during the Vietnam era) were interviewed by telephone with a structured psychiatric diagnostic interview. Covered in the interview were DSM-III-R lifetime criteria for dependence and abuse on 5 illicit and 2 licit drug classes, as well as other psychiatric disorders. The availability of ages of onset and offset for each drug-class specific symptom of addiction in these data make them uniquely suitable for a method of studying transitions to drug addiction that we have already used successfully with alcohol symptom data. The twin structure of the data permits study of the effect of genetic factors on occurrence and transitions to addiction on specific drugs. Specifically we will: 1) explore the nosology of drug-class specific addictions and investigate the role of genetic factors in the classifications, using latent structure techniques like latent class analysis; 2) investigate transitions in addiction in both epidemiologic and genetic frameworks, using a) a more conventional approach that relies on drug use patterns (e.g. initiation, regular and problem use), as well as b) a novel approach based on person-years of addiction symptoms, developing a method for incorporating symptom offsets; 3) study factors (including use of other substances, psychiatric comorbidity, social characteristics, family history) that may promote, accelerate, or inhibit transitions; and 4) conduct, wherever possible, cross-study analyses using other sources of data, especially data from the Vietnam Era Study (VES), National Comorbidity Survey (NCS), National Longitudinal Alcohol Epidemiology Survey (NLAES), and the Collaborative Study on the Genetics of Alcoholism (COGA), in order to test the replicability of the findings. We expect our proposed analyses will contribute to an understanding of transitions in addiction to specific types of drugs. Ultimately, our research may suggest certain points in transitions in specific drug addictions that might be amenable to preventive interventions.