NCI TRANSITION CAREER DEVELOPMENT AWARD

NCI 过渡职业发展奖

• 批准号: 6620136
• 负责人: THERESA W GILLESPIE
• 金额: $ 15.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620136
• 关键词: behavioral /social science research tag; cancer risk; clinical research; clinical trials; decision making; human subject; informed consent; medical outreach /case finding; neoplasm /cancer; neoplasm /cancer therapy; outcomes research; therapy compliance

DESCRIPTION: (Applicant's Description) The purpose of this award is to provide 75 percent "protected time" for the Candidate, as a newly-independent investigator, to develop a research program drawing on previous experiences in clinical, translational, and cancer prevention/control sciences. As Director of Clinical Research in a University-based Cancer Center, the Candidate is in a unique and ideal position to develop a comprehensive program investigating the educational, behavioral, cognitive, and applied ethical aspects of oncology clinical trials. The proposed Research Plan addresses issues raised in PA-99-079, "Research on Ethical Issues in Human Studies", and an R01 application will be submitted to the NIH in response to this PA. Preliminary work in this area has already been conducted by the Candidate. The hypothesis of the proposal is: The current approach used for informed decision-making by potential subjects for oncology clinical trials impedes the ability of patients to comprehend the essential elements of research studies, and impacts effective recruitment, retention, and compliance for these trials. The specific aims of the project are to: 1) investigate the effects of specific interventions on potential subjects' measured comprehension of clinical trials; 2) determine the outcomes of different strategies for oncology patient recruitment, retention, and compliance; 3) compare the risk:benefit appraisal process used by potential subjects in oncology vs. non-oncology settings; and 4) study the consequences of planned and possible future use of collected tissues or cells as laboratory correlates on decision-making about therapeutic trials. The initial year of the project will be directed toward completion of analysis and publication of preliminary data, with submission of the R01 application by the end of Year 2. By the conclusion of the third year of the program, the Candidate should be well-positioned to implement a program of independent research with extramural funding support. Findings from these investigations would contribute toward significantly improving outcomes in clinical trials as well as the ability to accrue adequate numbers of subjects to answer critical questions in cancer prevention, therapy, and correlative science.

描述：（申请人的描述）该奖项的目的是 作为新独立的候选人提供75％的“受保护时间” 研究者，制定研究计划，了解以前的经验 临床，转化和癌症预防/控制科学。 作为导演 在大学癌症中心的临床研究中，候选人正在 一个独特而理想的位置，用于制定一个综合计划调查 教育，行为，认知和应用的道德方面 肿瘤学临床试验。 拟议的研究计划解决了提出的问题 在PA-99-079中，“人类研究中的道德问题研究”和R01 申请将对此PA提交给NIH。 初步的 该领域的工作已经由候选人进行。 假设 该提议的是：当前用于知情决策的方法 肿瘤学临床试验的潜在受试者阻碍了 患者理解研究的基本要素，并影响 这些试验的有效招聘，保留和遵守。 这 该项目的具体目的是：1）研究特定的影响 对潜在受试者对临床的测量理解的干预措施 试验； 2）确定肿瘤患者不同策略的结果 招聘，保留和合规； 3）比较风险：收益评估 潜在受试者在肿瘤学与非肿瘤学设置中使用的过程；和 4）研究收集到的计划和未来使用的后果 组织或细胞作为实验室与治疗的决策相关 试验。 该项目的第一年将针对完成 在提交R01的提交中，分析和发布初步数据 在第2年底之前的申请。 计划，应对候选人进行良好的定位，以实施 独立研究，并提供校外资金支持。 这些发现 调查将有助于大大改善结果 临床试验以及获得足够数量的受试者的能力 回答预防癌症，治疗和相关性的关键问题 科学。