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TERWILLIGER LLNL & UC PRT

TERWILLIGER LLNL & UC PRT
特威利格有限责任公司
批准号：
6586579
负责人：
THOMAS C. TERWILLIGER
金额：
$14.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-03-01 至 2003-02-28
来源：
https://reporter.nih.gov/project-details/6586579
关键词：
bioimaging /biomedical imaging biomaterials biomedical resource proteins radiography structural biology

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英文摘要
Multiwavelength anomalous dispersion (MAD) data using anomalous scattering from selenium and iron will be used to determine the structure of ferric iron binding protein (FBP) from Haemophilus influenzae. This protein is vital to several pathogenic bacteria and is a promising target of structure-based drug design. Attempts to determine the crystal structure by traditional methods have been extremely frustrating. Very strong anomalous scattering from the iron atom along with incorporated seleno-methionine will make this an ideal candidate for MAD phasing. The crystals diffract to 1.6  resolution.
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会议论文
Structures of Mtb proteins conferring susceptibility to known Mtb inhibitors
  • 批准号：
    8153423
  • 项目类别：
  • 资助金额：
    $36.37万
  • 财政年份：
    2010
  • 负责人：
    THOMAS C. TERWILLIGER
  • 依托单位：
    TEXAS A&M UNIVERSITY
PROJECT 2 - MODEL COMPLETION AND VALIDATION
Parent Project
Integrated Center for Structure and Function Innovation
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