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ANNEXIN PHOSPHOLIPID COMPLEX & HIGH RESOLUTION PBP

ANNEXIN PHOSPHOLIPID COMPLEX & HIGH RESOLUTION PBP
膜联蛋白磷脂复合物
批准号:
6586753
负责人:
HARTMUT LUECKE
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28

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中文摘要
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英文摘要
Annexins are a family of calcium- and phospholipid-binding proteins implicated in membrane fusion and ion channel formation. We have now obtained small crystals of annexin XII co-crystallized with phospholipid analogs. We propose to solve the structure of the annexin XII hexamer:phospholipid analog complex in the presence of calcium. 18 calcium sites on the perimeter of the disk shaped hexamer are accessible to the bulk solvent. The detailed atomic structure of this complex would provide new insight into the binding mode of the phospholipid headgroups to annexin XII.
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Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    8707937
  • 项目类别:
  • 资助金额:
    $50.45万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    8214645
  • 项目类别:
  • 资助金额:
    $47.54万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    7894088
  • 项目类别:
  • 资助金额:
    $4.05万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    7755800
  • 项目类别:
  • 资助金额:
    $48.02万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
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