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STAFF PRIORITY TIME SOLUTION SCATTERING STUDIES ON ANNEXIN XII ASSEMBLY

STAFF PRIORITY TIME SOLUTION SCATTERING STUDIES ON ANNEXIN XII ASSEMBLY
附件 XII 大会上的工作人员优先时间解决方案分散研究
批准号:
6586775
负责人:
HARTMUT LUECKE
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28

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中文摘要
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英文摘要
We studied three site-directed mutants of annexin XII (E105K, E105K/K68A, E105K/K68A/E76A), aimed at investigating the roles of amino acid residues participating in the intermolecular interaction which plays an important role in the Ca2+-induced hexamer formation. We observed significantly smaller radii of gyration with E105K in the presence of saturated amounts of Ca2+ as compared to the wild type protein in an identical solution condition. The hexamer formation is significantly diminished for the double and triple mutants as expected from the crystal structure. Thus we conclude that these amino acid residues are crucial in the Ca2+-induced oligomer formation.
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Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    8707937
  • 项目类别:
  • 资助金额:
    $50.45万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    8214645
  • 项目类别:
  • 资助金额:
    $47.54万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    7894088
  • 项目类别:
  • 资助金额:
    $4.05万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
  • 批准号:
    7755800
  • 项目类别:
  • 资助金额:
    $48.02万
  • 财政年份:
    2008
  • 负责人:
    HARTMUT LUECKE
  • 依托单位:
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