CRYSTALLOGRAPHIC STUDIES OF BLOOD CLOTTING PROTEINS

血液凝固的一个显著特征是 对过程的控制。 虽然功能正常，但血液 不应该凝结，同样，当它是适当的，血液应该 快速且牢固地凝块。 我们有兴趣确定 一些分子的晶体结构 凝血控制（因子XIII-抑制剂复合物，玉米Hageman 因子抑制剂，肝素辅因子II）。 虽然我们已经解决了 在第十三因子酶原的结构中，我们现在有小晶体， 这些复合物和分子需要使用同步加速器 辐射来完成它们的结构分析，

One striking characteristic of blood coagulation is the fine level of control placed on the process. While functioning normally, blood should not clot, and likewise, when it is appropriate, blood should clot quickly and firmly. We are interested in determining the crystallographic structures of several of the molecules that keep clotting under control (factor XIII-inhibitor complexes, corn Hageman factor inhibitor, heparin co-factor II). While we have solved the structure of the factor XIII zymogen, we now have small crystals of these complexes and molecules that will require the use of synchrotron radiation to complete their structure analyses,