CRYSTALLOGRAPHIC STUDIES OF BLOOD CLOTTING PROTEINS

血液凝固的一个显著特征是细微的水平 对过程的控制力。在功能正常的情况下，血液 不应该凝结，同样，当它合适的时候，血液应该 快速而牢固地凝结。我们有兴趣确定 几种保持稳定的分子的晶体结构 凝血得到控制(凝血因子XIII-抑制物复合体，玉米Hageman 因子抑制物、肝素辅助因子II)。虽然我们已经解决了 结构，我们现在有了小晶体 这些需要使用同步加速器的络合物和分子 以完成它们的结构分析，

One striking characteristic of blood coagulation is the fine level of control placed on the process. While functioning normally, blood should not clot, and likewise, when it is appropriate, blood should clot quickly and firmly. We are interested in determining the crystallographic structures of several of the molecules that keep clotting under control (factor XIII-inhibitor complexes, corn Hageman factor inhibitor, heparin co-factor II). While we have solved the structure of the factor XIII zymogen, we now have small crystals of these complexes and molecules that will require the use of synchrotron radiation to complete their structure analyses,