XRAY DIFFRACTION OF C TERMINAL DOMAIN OF RALGDS & ITS COMPLEX W/ RAS GMPPNP
XRAY DIFFRACTION OF C TERMINAL DOMAIN OF RALGDS & ITS COMPLEX W/ RAS GMPPNP
批准号:
6586601
负责人:
Lan Huang
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
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英文摘要
Ras protein is a molecular switch in signal transduction pathways
that control cell growth and differentiation. In human cells, point
mutations in crucial regions of Ras can cause uncontrolled cell
growth, or tumors. At least 30% of human cancers show the presence of
mutationally activated Ras. Structural studies of Ras-GTP with its
effectors and putative effectors will contribute greatly to the
understanding of the molecular mechanism of the interaction and Ras
inhibitors design. Our studies on Ras and RalGDS will enable us to
further understand the structural basis for molecular communication in
this system.
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