XRAY DIFFRACTION OF C TERMINAL DOMAIN OF RALGDS & ITS COMPLEX W/ RAS GMPPNP

RALGDS C 端域的 X 射线衍射

• 批准号: 6586601
• 负责人: Lan Huang
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586601
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; growth /development; proteins; radiography; structural biology

Ras protein is a molecular switch in signal transduction pathways that control cell growth and differentiation. In human cells, point mutations in crucial regions of Ras can cause uncontrolled cell growth, or tumors. At least 30% of human cancers show the presence of mutationally activated Ras. Structural studies of Ras-GTP with its effectors and putative effectors will contribute greatly to the understanding of the molecular mechanism of the interaction and Ras inhibitors design. Our studies on Ras and RalGDS will enable us to further understand the structural basis for molecular communication in this system.

Ras蛋白是信号转导通路中的分子开关