CRYSTALLOGRAPHIC STUDIES ON ICOSAHEDRAL CORE OF PYRUVATE DEHYDROGENASE COMPLEX
CRYSTALLOGRAPHIC STUDIES ON ICOSAHEDRAL CORE OF PYRUVATE DEHYDROGENASE COMPLEX
批准号:
6658613
负责人:
TINA IZARD
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
了解二十面体的三维结构
核心和PDH复合物的羧化酶组分将导致
非常完整的架构,动力学和催化作用,
生物体中最复杂的多酶复合体之一
cell. 复合体的缺陷或故障导致严重的
病理状态,例如通常
与严重的神经功能障碍有关
英文摘要
Understanding the three-dimensional structures of the icosahedral
core and the carboxylase component of the PDH complex will lead to a
very complete picture of the architecture, dynamics and catalysis of
one of the most complicated multienzyme complexes found in the living
cell. Deficiencies or malfunctioning of the complexes lead to severe
pathological states such as numerous acidoses which are usually
correlated with serious neurological dysfunctions.
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会议论文
Molecular Mechanisms of Cell Adhesion
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批准号:10459227
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项目类别:
-
资助金额:$48.3万
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财政年份:2021
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负责人:TINA IZARD
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依托单位:
Molecular Mechanisms of Cell Adhesion
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批准号:10604429
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项目类别:
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资助金额:$35.78万
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财政年份:2021
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负责人:TINA IZARD
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依托单位:
Mechanisms Directing Adherens Junctions and Actin Network Interactions
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批准号:8327729
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项目类别:
-
资助金额:$37.62万
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财政年份:2011
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负责人:TINA IZARD
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依托单位:
X-RAY DATA COLLECTION OF PROTEINS INVOLVED IN CELL ADHESION
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批准号:8362252
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项目类别:
-
资助金额:$0.22万
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财政年份:2011
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负责人:TINA IZARD
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依托单位:
Mechanisms Directing Adherens Junctions and Actin Network Interactions
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批准号:8107239
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项目类别:
-
资助金额:$37.62万
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财政年份:2011
-
负责人:TINA IZARD
-
依托单位:
Mechanisms directing adherens junctions and actin network interactions
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批准号:9315846
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项目类别:
-
资助金额:$38.63万
-
财政年份:2011
-
负责人:TINA IZARD
-
依托单位:
Mechanisms Directing Adherens Junctions and Actin Network Interactions
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批准号:8523912
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项目类别:
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资助金额:$36.3万
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财政年份:2011
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负责人:TINA IZARD
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依托单位:
Mechanisms directing adherens junctions and actin network interactions
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批准号:9913186
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项目类别:
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资助金额:$9.53万
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财政年份:2010
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负责人:TINA IZARD
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依托单位:
X-RAY DATA COLLECTION OF PROTEINS INVOLVED IN CELL ADHESION
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批准号:8170212
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项目类别:
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资助金额:$0.2万
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财政年份:2010
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负责人:TINA IZARD
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依托单位:
Structural Dynamics of Vinculin in Adhesion Junctions
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批准号:7931154
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项目类别:
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资助金额:$24.83万
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财政年份:2009
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负责人:TINA IZARD
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依托单位:
X-RAY DATA COLLECTION OF PROTEINS INVOLVED IN CELL ADHESION
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批准号:7954557
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项目类别:
-
资助金额:$0.1万
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财政年份:2009
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负责人:TINA IZARD
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依托单位:
Pathogen-host Interactions that Remodel the Cytoskeleton
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批准号:7508954
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项目类别:
-
资助金额:$44.15万
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财政年份:2006
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负责人:TINA IZARD
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依托单位:
Pathogen-host Interactions that Remodel the Cytoskeleton
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批准号:7026791
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项目类别:
-
资助金额:$37.86万
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财政年份:2006
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负责人:TINA IZARD
-
依托单位:
Pathogen-host Interactions that Remodel the Cytoskeleton
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批准号:7760920
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项目类别:
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资助金额:$42.42万
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财政年份:2006
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负责人:TINA IZARD
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依托单位:
Pathogen-host Interactions that Remodel the Cytoskeleton
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批准号:7342056
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项目类别:
-
资助金额:$43.82万
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财政年份:2006
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负责人:TINA IZARD
-
依托单位:
Pathogen-host Interactions that Remodel the Cytoskeleton
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批准号:7169581
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项目类别:
-
资助金额:$35.73万
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财政年份:2006
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负责人:TINA IZARD
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依托单位:
MYCOBACTERIUM TUBERCULOSIS PHOSPHOPANTETHEINE ADENYLTRANSFERASE
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批准号:7182516
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项目类别:
-
资助金额:$0.61万
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财政年份:2005
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负责人:TINA IZARD
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依托单位:
STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONS
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批准号:7471319
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项目类别:
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资助金额:$23.43万
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财政年份:2004
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负责人:TINA IZARD
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依托单位:
STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONS
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批准号:7675850
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项目类别:
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资助金额:$10.86万
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财政年份:2004
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负责人:TINA IZARD
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依托单位:
Structural Dynamics of Vinculin in Adhesion Junctions
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批准号:7654239
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项目类别:
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资助金额:$40.42万
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财政年份:2004
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负责人:TINA IZARD
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依托单位:
海外基金