SIV ENCEPHALITIS IS ASSOCIATED W/ RAPID DISEASE PROGRESSION

中枢神经系统（CNS）疾病是猿猴的主要特征 免疫缺陷病毒（SIV）感染的猕猴 SIV感染猕猴中枢神经系统病变谱和潜在的 与病毒株和病程的关系，我们进行了一项 124例SIV感染猕猴尸检的回顾性分析 在71例（57.3%）中观察到CNS疾病的组织学证据。 124只动物中，SIV脑炎是最常见的中枢神经系统病变 43.7%（31/71）的CNS疾病动物和25.0%（21/71）的 所有动物SIVE的发生率与 生存期缩短（P= 0.0207），SIVE发生率为42.9% (15/35）的快速进展者（200天内死亡的动物） 相比之下，只有18%（16/89）的正常进展者（存活的动物 超过200天）（P= 0.011）SIVE动物的病毒感染率较高， 比那些没有，但这种差异 没有达到统计学上的显著性。同样， 未克隆SIVmac 251感染者SIVE发病率较高（27 5%; 14/51）比感染分子克隆SIVmac 239的动物高， 其T细胞嗜性衍生物（18.5%; 10/54），这种差异不 在本研究中，疾病进展迅速， SIVE高度相关，使分离的病毒决定因素， 毒力来自神经毒力困难出版物 Westmoreland SV，Halpern E，Lackner AA猿猴免疫缺陷病毒 恒河猴脑炎是一种与快速发病有关的疾病 进展J Neurovirol 4：260-268，1998

Central nervous system (CNS) disease is a major feature of simian immunodeficiency virus (SIV) infection of macaques To define the spectrum of CNS lesions in SIV-infected macaques and the potential associations with viral strain and disease course, we performed a retrospective analysis of necropsies on 124 macaques with SIV-induced AIDS Histologic evidence of CNS disease was observed in 71 (57 3%) of the 124 animals SIV encephalitis was the most common CNS lesion occurring in 43 7% (31/71) of the animals with CNS disease and 25% of all animals The incidence of SIVE correlated significantly with shortened survival (P=0 0207) In addition, SIVE was seen in 42 9% (15/35) of rapid progressors (animals that died within 200 days) compared to only 18% (16/89) of normal progressors (animals that lived longer than 200 days) (P=0 011) Animals with SIVE had higher viral loads in peripheral blood than those that did not, but this difference did not reach statistical s igni ficance Similarly, while animals infected with uncloned SIVmac251 had a higher incidence of SIVE (27 5%; 14/51) than animals infected with molecularly cloned SIVmac239 and its T-cell tropic derivatives (18 5%; 10/54) this difference was not statistically significant In this study rapid disease progression and SIVE were highly correlated making separation of viral determinants of virulence from those of neurovirulence difficult Publications Westmoreland SV, Halpern E, Lackner AA Simian immunodeficiency virus encephalitis is rhesus macaques is associated with rapid disease progression J Neurovirol 4:260-268, 1998