COMMON LIFE STRESSES & FERTILITY IN PRIMATES

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 该项目研究日常生活压力在导致女性和非人类灵长类动物不孕症中的作用。它建立在我们以前的发现基础上，即有些人对压力非常敏感，容易表现出压力引起的生殖功能抑制，而另一些人则具有压力弹性，在压力下保持正常的月经周期。我们已经发现，与更具压力弹性的个体相比，压力敏感的个体显示出较低的中枢多巴胺能神经元活性，这在生理学上和基因表达的变化中都有所表现。在这项补助金中，具体目标1是确定使用选择性5-羟色胺再摄取抑制剂（SSRI）治疗是否会增加压力敏感个体的压力恢复力。具体目标2是确定在基因表达和活性的中枢神经系统的压力敏感和压力弹性的个人。具体目标3检查活动的下丘脑-垂体-肾上腺（HPA）轴在压力敏感与压力弹性的动物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress resilience of stress-sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitive vs. stress-resilient animals.