COMMON LIFE STRESSES & FERTILITY IN PRIMATES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这个项目调查了日常生活压力在导致女性和非人类灵长类动物不孕不育方面所起的作用。它建立在我们之前的发现基础上，即一些人对压力非常敏感，很容易表现出压力诱导的生殖功能抑制，而另一些人则具有压力弹性，在压力下保持正常的月经周期。我们发现，与更具应激弹性的个体相比，应激敏感个体的中枢5-羟色胺能神经元活性较低，这在生理上和基因表达的变化上都表明了这一点。在这项资助中，具体目标1是确定选择性5-羟色胺再摄取抑制剂(SSRI)的治疗是否会增加应激敏感个体的应激恢复能力。具体目标2是确定应激敏感和应激恢复个体中枢神经系统基因表达和活性的差异。具体目标3检测压力敏感型和应激恢复型动物下丘脑-垂体-肾上腺(HPA)轴的活性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress resilience of stress-sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitive vs. stress-resilient animals.