COMMON LIFE STRESSES & FERTILITY IN PRIMATES

常见的生活压力

• 批准号: 8357732
• 负责人: JUDY L CAMERON
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357732
• 关键词: Animals; Build-it; Fertility; Funding; Gene Expression; Grant; Individual; Infertility; Life Stress; Menstrual cycle; National Center for Research Resources; Neurons; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Selective Serotonin Reuptake Inhibitor; Source; Stress; System; United States National Institutes of Health; Woman; cost; hypothalamic-pituitary-adrenal axis; nonhuman primate; relating to nervous system; reproductive function; stress resilience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress resilience of stress-sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitive vs. stress-resilient animals.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目研究了日常生活强调在导致女性和非人类灵长类动物的不孕症中起作用的作用。它基于我们以前的发现，有些人对压力非常敏感，并且很容易表现出压力引起的生殖功能的抑制，而另一些人则在压力时具有压力弹性，并且在压力时保持正常的月经周期。我们发现，与更具应激的个体相比，对压力敏感的个体表现出较低的中枢性血清素能神经元活性，如生理上和基因表达的变化所示。在这笔赠款中，具体目标1是确定选择性5-羟色胺再摄取抑制剂（SSRI）是否会增加对压力敏感个体的应激弹性。具体目的2是确定压力敏感和应激性个体中中枢神经系统基因表达和活性的差异。具体目标3检查了应激敏感性与应激耐力动物中下丘脑 - 垂体 - 肾上腺（HPA）轴的活性。