EFFECTS OF COMMON LIFE STRESSES ON FERTILITY

共同生活压力对生育力的影响

基本信息

  • 批准号:
    8125587
  • 负责人:
  • 金额:
    $ 6.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-04-01 至 2011-03-31
  • 项目状态:
    已结题

项目摘要

The overall goal of this project renewal is to determine the mechanisms by which common life stresses (i.e., dieting, moderate exercise and psychological stress) impair activity of the reproductive axis and fertility. Female cynomolgus monkeys, which like women have 28-day menstrual cycles throughout the year, show individual differences in responsiveness to stress, with stress-sensitive animals rapidly developing stressinduced reproductive dysfunction, medium stress-resilient animals developing stress-induced reproductive dysfunction after sustained stress exposure, and highly stress-resilient animals maintaining normal menstrual cyclicity throughout stress exposure. Interestingly, all monkeys show a significant impairment of fertility with stress exposure. The stress used for these studies is patterned after that documented in women with Hypothalamic Amenorrhea, who generally experience increased psychosocial stress combined with a mild metabolic stress (resulting from dieting and exercise). Monkeys are exposed to a combination of mild psychosocial stress (moving monkeys to a new housing room) + a moderate diet (20% decrease in calorie intake) + moderate exercise (running at a moderate pace for 1 hour, 5 days a week). We identified several stable characteristics associated with stress-sensitivity: lower follicular phase estradiol secretion, lower luteal phase progesterone secretion, higher heart rate, increased anxious behavior, lower activity of the brain serotonin system, and increased gene expression in hypothalamic GABAergic neurons. Our findings suggest that common life stresses have a more significant impact on both circulating levels of reproductive hormones and fertility than previously appreciated, particularly in stress-sensitive individuals. The specific aims of this renewal are: (1) to determine whether increasing brain serotonin levels by chronic treatment with a serotonin reuptake inhibitor (SSRI; a common anti-anxiety medication) will improve stress resilience, (2) identify further differences in neural circuits in stress-sensitive versus stress-resilient individuals, and (3) determine whether stress exposure has a negative impact at the level of the ovary on oocyte viability, early embryo development and ovarian cell steroidogenic capacity. The proposed studies will further our understanding of how common life stresses impact reproductive function, with the long-term goal of developing new treatments to make stress-sensitive individuals more stress resilient.
本项目更新的总体目标是确定日常生活压力(即,

项目成果

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JUDY L CAMERON其他文献

JUDY L CAMERON的其他文献

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{{ truncateString('JUDY L CAMERON', 18)}}的其他基金

The impact of early life stress on the immature primate amygdala: influence on mental health trajectories
早期生活压力对未成熟灵长类杏仁核的影响:对心理健康轨迹的影响
  • 批准号:
    10283522
  • 财政年份:
    2021
  • 资助金额:
    $ 6.69万
  • 项目类别:
The impact of early life stress on the immature primate amygdala: influence on mental health trajectories
早期生活压力对未成熟灵长类杏仁核的影响:对心理健康轨迹的影响
  • 批准号:
    10442727
  • 财政年份:
    2021
  • 资助金额:
    $ 6.69万
  • 项目类别:
Education Outreach Core
教育外展核心
  • 批准号:
    10379351
  • 财政年份:
    2019
  • 资助金额:
    $ 6.69万
  • 项目类别:
Education Outreach Core
教育外展核心
  • 批准号:
    10613347
  • 财政年份:
    2019
  • 资助金额:
    $ 6.69万
  • 项目类别:
COMMON LIFE STRESSES & FERTILITY IN PRIMATES
常见的生活压力
  • 批准号:
    8357732
  • 财政年份:
    2011
  • 资助金额:
    $ 6.69万
  • 项目类别:
GENETIC LINKS TO ALCOHOLISM IN A NONHUMAN PRIMATE SPECIES
非人类灵长类物种与酗酒的遗传联系
  • 批准号:
    8173200
  • 财政年份:
    2010
  • 资助金额:
    $ 6.69万
  • 项目类别:
Polycystic Ovarian Syndrome Model: Androgen-Treated Pubertal Monkeys
多囊卵巢综合症模型:雄激素治疗的青春期猴
  • 批准号:
    7875392
  • 财政年份:
    2010
  • 资助金额:
    $ 6.69万
  • 项目类别:
Role of Serotonin in Mediating Stress-Induced Infertility
血清素在调节压力引起的不孕症中的作用
  • 批准号:
    8294451
  • 财政年份:
    2010
  • 资助金额:
    $ 6.69万
  • 项目类别:
Role of Serotonin in Mediating Stress-Induced Infertility
血清素在调节压力引起的不孕症中的作用
  • 批准号:
    8110004
  • 财政年份:
    2010
  • 资助金额:
    $ 6.69万
  • 项目类别:
ANDROGEN EXPOSURE AND ACTIONS IN PRE- TO PERIPUBERTAL MONKEYS
青春期前猴子的雄激素暴露和作用
  • 批准号:
    8173202
  • 财政年份:
    2010
  • 资助金额:
    $ 6.69万
  • 项目类别:

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  • 批准号:
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