GENETIC LINKS TO ALCOHOLISM IN A NONHUMAN PRIMATE SPECIES

非人类灵长类物种与酗酒的遗传联系

• 批准号: 8173200
• 负责人: JUDY L CAMERON
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173200
• 关键词: Alcohol consumption; Alcoholism; Ataxia; Behavior; Behavioral; Cerebrospinal Fluid; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Genetic; Goals; Grant; Institution; Link; Measures; Monkeys; Phenotype; Physiological; Population; Research; Research Personnel; Resources; Serotonin; Source; Testing; United States National Institutes of Health; alcohol behavior; genetic linkage analysis; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are: (1) to test whether behavioral and physiological markers that have been linked to increased consumption of alcohol in clinical studies can be measured in a population of monkeys, (2) to test whether there is evidence in the monkey that these behaviors/physiological markers are heritable, and (3) to utilize our previously collected genotypic data in each monkey for linkage analysis to identify chromosomal regions carrying genetic information about phenotypes linked to alcoholism in clinical populations. Phenotypes being assessed include: anxious behaviors, alcohol-induced ataxia and CSF serotonin levels in cerebrospinal fluid.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是：（1）测试是否可以在猴子群体中测量临床研究中与饮酒增加相关的行为和生理标记，（2）测试猴子中是否有证据表明这些行为/生理标记是可遗传的，以及（3）利用我们之前收集的每只猴子的基因型数据进行连锁分析，以识别携带相关遗传信息的染色体区域 与临床人群中酗酒相关的表型。正在评估的表型包括：焦虑行为、酒精引起的共济失调和脑脊液中的脑脊液血清素水平。