GENETIC LINKS TO ALCOHOLISM IN A NONHUMAN PRIMATE SPECIES

非人类灵长类物种与酗酒的遗传联系

• 批准号: 8173200
• 负责人: JUDY L CAMERON
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173200
• 关键词: Alcohol consumption; Alcoholism; Ataxia; Behavior; Behavioral; Cerebrospinal Fluid; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Genetic; Goals; Grant; Institution; Link; Measures; Monkeys; Phenotype; Physiological; Population; Research; Research Personnel; Resources; Serotonin; Source; Testing; United States National Institutes of Health; alcohol behavior; genetic linkage analysis; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are: (1) to test whether behavioral and physiological markers that have been linked to increased consumption of alcohol in clinical studies can be measured in a population of monkeys, (2) to test whether there is evidence in the monkey that these behaviors/physiological markers are heritable, and (3) to utilize our previously collected genotypic data in each monkey for linkage analysis to identify chromosomal regions carrying genetic information about phenotypes linked to alcoholism in clinical populations. Phenotypes being assessed include: anxious behaviors, alcohol-induced ataxia and CSF serotonin levels in cerebrospinal fluid.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目标是：（1）测试与临床研究中与酒精消耗有关的行为和生理标志物是否可以在猴子种群中衡量，（2）测试猴子中是否有证据表明这些行为/生理标记是否具有遗传性，并且（3）在每个猴子中均涉及我们先前收集的杂物分析，以识别猴子的杂物分析。与临床人群中酒精中毒有关的表型。评估的表型包括：脑脊液中的焦虑行为，酒精诱发的共济失调和CSF 5-羟色胺水平。