BIOENGINEERING TRAINING CARDIOVASCULAR PATHOPHYSIOLOGY

描述 (改编自申请人的摘要)这项新的跨学科建议 心血管病理生理学生物工程培训助学金中心 最近成立的医学与工程研究所(IME)，以及 宾夕法尼亚大学的校际倡议。这项建议 认识到有必要在预科和临床阶段培训研究和临床研究员 定量心血管病理生理学博士后水平 尤其是当它与分子的生物医学工程有关时， 细胞和组织水平。假设驱动和设计驱动的方法 到知识的问题将会得到解决。14个跨学科基础和临床 生物工程和生物医学研究的科学家在IME内互动 与该研究所的另外45名成员进行协作外联。这个 核心培训调查员将获得约1,000万美元(主要是 NIH和NSF)研究拨款支持，另有900万美元待批拨款 支持。培训教员中有八人是正职或副教授 以及6位杰出的助理教授。IME及其状态- 一流的研究实验室和核心实验室设施都毗邻 医学院和工程学院。一个备受关注的基准 跨学科研讨会系列(46场/年)将发展为 完整的课程，以及一门新的机械传导学研究生课程 共同提出补充现有跨学科研究生课程 有密集的短期课程和专门的负责任的科学实践 当然了。首次拟招收3名博士后和3名博士后实习生 每年增加一次，直到第4年(稳态6/6)。二 通常会提供多年的支持。学员将被挑选出来 在由5名教职员工组成的指导委员会进行竞争性审查后， 精心平衡，以体现赠款的跨学科性质。 实习生的选择将基于学业成绩、质量 研究能力和对跨学科研究的承诺 心血管生物学。博士后医学博士和/或博士实习生将 预计在他们的训练期间将发展出显著的独立性。 博士前实习生将注册参加该研究所的一个研究生项目 生物医学研究生小组(基础科学，MSTP)或生物工程， 学校化学工程、机械工程专业毕业生群体 工程学专业。将要求或鼓励博士后实习生 完成42小时的心血管生物学机械转导课程； 所有受训人员必须完成研讨会/杂志俱乐部/讨论 当然了。IME与所有临床和基础科室广泛互动 两所学校都有。对1)少数族裔招聘工作的响应能力，以及2) 研究的合乎道德的行为，都有记录。外部咨询委员会 被命名为。

DESCRIPTION (Adapted from applicant's abstract) This new interdisciplinary proposal for a Bioengineering Training Grant in Cardiovascular Pathophysiology is center in the recently established Institute for Medicine and Engineering (IME), an interschool initiative at the University of Pennsylvania. The proposal recognizes the need to train research and clinical fellows at the pre- and postdoctoral levels in quantitative cardiovascular pathophysiology particularly as it pertains to biomedical engineering at the molecular, cellular, and tissue levels. Hypothesis-driven and design-driven approaches to knowledge will be addressed. Fourteen interdisciplinary basic and clinical scientists in bioengineering and biomedical research interact within the IME with collaborative outreach to an additional 45 Members of the Institute. The core training investigators are recipient of approximately $10m (principally NIH and NSF) research grant support, with an additional $9m pending grant support. Eight of the training faculty are Full or Associate Professors together with 6 outstanding Assistant Professors. The IME with its state-of- the-art research labs and core laboratory facilities is adjacent to both the School of Medicine and the School of Engineering. A well-attended benchmark Interdisciplinary Seminar Series (46 lectures/year) will be developed to a full course, and a new graduate course in mechanotransduction that will complement current interdisciplinary graduate courses is proposed together with intensive short-courses, and a specialized Practicing Responsible Science course. Three pre- and 3 postdoctoral trainees are proposed for the first year increasing by one each year up to the 4th year (steady state 6/6). Two years of support will normally be provided. Trainees will be selected following competitive review by a Steering Committee of 5 faculty that will be carefully balanced to represent the interdisciplinary nature of the grant. Trainee selections will be made on the basis of academic record, quality of research abilities, and commitment to research in interdisciplinary cardiovascular biology. Postdoctoral M.D. and/or Ph.D. trainees will be expected to develop significant independence during their training period. Predoctoral trainees will be registered in one of the graduate programs of the Biomedical Graduate Group (Basic science, MSTP) or the Bioengineering, Chemical Engineering, and Mechanical Engineering Graduate Groups of the School of Engineering. Predoctoral trainees will be required or encourage to complete a 42 hour course in mechanotransduction in cardiovascular biology; all trainees are required to complete the Seminars/Journal Club/Discussion course. The IME interacts extensively with all clinical and basic departments of both schools. Responsiveness to 1) minority recruitment efforts, and 2) ethical conduct of research, are documented. An External Advisory Committee is named.