Training Program in Biomedical Imaging and Informational Sciences

描述（申请人提供）：临床相关影像科学定量基础科学家的培养日益重要。优秀的成像科学在宾夕法尼亚大学的多个学院中都有很好的体现，但在研究生培训中没有正式的整合努力，在生物医学成像和信息科学培训计划创建之前，也没有正式的临床培训部分。该项目于2006年在HHMI-NIBIB接口倡议的支持下成立，由医学与工程研究所和放射科领导，与多所学校的许多其他部门合作。我们的前提是定量成像科学中最成功的研究和技术是那些整合临床相关性，数学严谨性和工程技巧的研究和技术。因此，该计划包括强大的临床暴露与分析成像科学。目标是通过确保学生达到一定的整合水平，从而发展一种新型的跨学科培训，使他们成为假设驱动的、临床重点生物医学成像研究的下一代领导者。迄今为止，所有影响指标的项目结果都很强劲，表明培训目标取得了成功进展：出版物（107）；众多研究奖项和荣誉；并招聘6名URM和弱势学员。一个正式的课程，博士基础，为该计划提供了18个月的垂直整合生物医学和生物医学成像基础科学教育的核心教学要素，通过4个组成部分，其中两个是基础，其次是综合和专业组成部分。在第一个阶段，生物医学科学基础（2门课程），学生参加修改后的医学生课程模块1和模块2，教授医学核心原理（包括大体解剖学）和12个月的器官系统医学、综合系统和疾病序列。影像科学基础4门课程：分子影像、生物医学影像分析、影像基础技术、医学影像与测量数学。第三部分是综合模块：高级生物医学成像应用和生物医学图像科学研讨会。第四部分是专业培训：负责任的研究行为、教学实习、以患者为导向的研究培训、研究“生存”技能和职业发展技能。核心课程辅以许多选修课程，这些课程由课程教师提供，并为生物医学成像量身定制。强制性的实验室轮转将通过参与教师的实验室提供。确保论文的研究方向是转化医学

DESCRIPTION (provided by applicant): The training of quantitative basic scientists in clinically-related imaging science is increasingly important. Excellent imaging sciences are well represented at Penn in multiple schools, but no formal integration of efforts in graduate training existed, nor was there a formal clinical component to the training until the creation of the Training Program in Biomedical Imaging and Informational Sciences. Established in 2006 under the auspices of the HHMI-NIBIB Interfaces Initiative, the program represents a partnership led by the Institute for Medicine and Engineering and the Department of Radiology in collaboration with many other Departments across multiple Schools. Our premise is that the most successful research and technologies in quantitative imaging science are those that integrate clinical relevance, mathematical rigor, and engineering finesse. Accordingly, the program embraces strong clinical exposure alongside analytical imaging science. The objective is to develop a new kind of interdisciplinary training by ensuring that students attain a level of integration that woud allow them to become the next generation of leaders in hypothesis-driven, clinically focused biomedical imaging research. Program outcomes to date are strong across all impact measures, indicating successful progress toward training objectives: publications (107); numerous research awards and distinctions; and recruitment of 6 URM and disadvantaged trainees. A formalized curriculum, the doctoral foundation, developed for the program provides 18 months of vertical integration of the core didactic elements of biomedicine and basic science education in biomedical imaging through 4 components, two of them Foundational, followed by Integrative and Professional components. In the first, Foundations in Biomedical Science (2 courses), students participate in modified modules 1 and 2 of the medical student curriculum that teaches the Core Principles of Medicine (including Gross Anatomy) and a 12- month sequence of organ systems medicine, Integrative Systems and Diseases. This is complemented by 4 courses in Foundations of Imaging Science: Molecular Imaging, Biomedical Image Analysis, Fundamental Techniques of Imaging, and Mathematics of Medical Imaging & Measurements. The third component is an Integrative Module: Advanced Biomedical Imaging Applications and Biomedical Image Sciences Seminars. The fourth component is Professional Training: Responsible Conduct of Research, Teaching Practicum, Patient-Oriented Research Training, Research 'Survival' Skills, and Career Development Skills. The core curriculum is complemented by many elective courses offered through the program faculty and tailored to Biomedical Imaging. Obligatory Laboratory Rotations will be offered through the laboratories of the participating faculty. To ensure that the thesis research is directed to translational medicine through the solution of discrete clinical problems, trainees will be co-advised by members of the clinical and basic science faculty.