Training Program in Biomedical Imaging and Informational Sciences

描述(由申请者提供)：临床相关影像科学的量化基础科学家的培训日益重要。优秀的成像科学在宾夕法尼亚大学的多所学校都有很好的表现，但研究生培训中的努力没有正式的整合，在生物医学成像和信息科学培训计划创建之前，也没有正式的临床培训内容。该计划于2006年在HHMI-NIBIB接口倡议的支持下建立，代表着由医学与工程研究所和放射科与多所学校的许多其他部门合作领导的合作伙伴关系。我们的前提是，定量成像科学中最成功的研究和技术是那些整合了临床相关性、数学严谨性和工程技巧的研究和技术。因此，该项目不仅包括分析成像科学，还包括强大的临床暴露。其目标是开发一种新的跨学科培训，确保学生达到一定程度的整合，使他们能够成为假设驱动的、专注于临床的生物医学成像研究的下一代领导者。到目前为止，所有影响指标的方案成果都很强劲，表明在实现培训目标方面取得了成功进展：发表了107份出版物；获得了许多研究奖项和荣誉；招募了6名URM和处境不利的学员。为该项目开发的正式课程--博士基础--提供了为期18个月的生物医学核心教学要素和生物医学成像基础科学教育的垂直整合，通过4个组成部分，其中两个组成部分是基础，其次是综合组成部分和专业组成部分。在第一门，生物医学基础(2门课程)中，学生们参加医学生课程修改后的模块1和模块2，教授医学核心原理(包括大体解剖学)和为期12个月的器官系统医学、综合系统和疾病序列。此外，还有4门成像科学基础课程：分子成像、生物医学图像分析、成像基本技术和医学成像与测量数学。第三部分是综合模块：高级生物医学成像应用和生物医学图像科学研讨会。第四个组成部分是专业培训：负责任的研究行为、教学实践、以病人为中心的研究培训、研究生存技能和职业发展技能。核心课程与许多选修课相辅相成，这些选修课是通过该项目的教职员工提供的，并为生物医学成像量身定做。强制性实验室轮换将通过参与的教职员工的实验室提供。确保论文研究的方向是转化医学 通过解决不同的临床问题，学员将得到临床和基础科学学院成员的共同建议。

DESCRIPTION (provided by applicant): The training of quantitative basic scientists in clinically-related imaging science is increasingly important. Excellent imaging sciences are well represented at Penn in multiple schools, but no formal integration of efforts in graduate training existed, nor was there a formal clinical component to the training until the creation of the Training Program in Biomedical Imaging and Informational Sciences. Established in 2006 under the auspices of the HHMI-NIBIB Interfaces Initiative, the program represents a partnership led by the Institute for Medicine and Engineering and the Department of Radiology in collaboration with many other Departments across multiple Schools. Our premise is that the most successful research and technologies in quantitative imaging science are those that integrate clinical relevance, mathematical rigor, and engineering finesse. Accordingly, the program embraces strong clinical exposure alongside analytical imaging science. The objective is to develop a new kind of interdisciplinary training by ensuring that students attain a level of integration that woud allow them to become the next generation of leaders in hypothesis-driven, clinically focused biomedical imaging research. Program outcomes to date are strong across all impact measures, indicating successful progress toward training objectives: publications (107); numerous research awards and distinctions; and recruitment of 6 URM and disadvantaged trainees. A formalized curriculum, the doctoral foundation, developed for the program provides 18 months of vertical integration of the core didactic elements of biomedicine and basic science education in biomedical imaging through 4 components, two of them Foundational, followed by Integrative and Professional components. In the first, Foundations in Biomedical Science (2 courses), students participate in modified modules 1 and 2 of the medical student curriculum that teaches the Core Principles of Medicine (including Gross Anatomy) and a 12- month sequence of organ systems medicine, Integrative Systems and Diseases. This is complemented by 4 courses in Foundations of Imaging Science: Molecular Imaging, Biomedical Image Analysis, Fundamental Techniques of Imaging, and Mathematics of Medical Imaging & Measurements. The third component is an Integrative Module: Advanced Biomedical Imaging Applications and Biomedical Image Sciences Seminars. The fourth component is Professional Training: Responsible Conduct of Research, Teaching Practicum, Patient-Oriented Research Training, Research 'Survival' Skills, and Career Development Skills. The core curriculum is complemented by many elective courses offered through the program faculty and tailored to Biomedical Imaging. Obligatory Laboratory Rotations will be offered through the laboratories of the participating faculty. To ensure that the thesis research is directed to translational medicine through the solution of discrete clinical problems, trainees will be co-advised by members of the clinical and basic science faculty.