Multidisciplinary Training in Cardiovascular Biology

描述（由申请人提供）：该竞争性更新HL 07954“心血管生物学多学科培训”是主要的NIH培训补助金，整合了宾夕法尼亚大学医学院（SOM），工程学院（SEAS）和艺术与科学学院（SAS）之间的研究。我们要求继续支持6名多学科心血管病理生理学的博士前和博士后培训人员，重点是综合生物医学-物理/定量/工程科学。32名教师导师分布在宾夕法尼亚大学的SOM，费城儿童医院，SEAS和SAS（物理;数学）部门，研究所和中心。该提案在5个关键领域解决了NHLBI多学科培训优先事项，确保（i）通过多学科心血管研究整合从分子到体内的全方位规模的培训广度和深度，（ii）增加教师，以确保在新的和不断发展的研究领域，包括新课程的开发，㈢每一对导师/受训人都需要一个正式的个人导师计划，（博士后）和博士后职位（Predocs），注重多样性，以及（v）包括基本翻译潜在科学家和临床研究员代表的翻译基础设施。为了维持一个充满活力的计划，Predocs和Postdocs将分别获得两年和三年的支持。学员由代表该项目跨学科性质的跨学校指导委员会通过竞争性审查选出。学员的选择是基于学术成绩，研究潜力和对跨学科心血管生物学的承诺。有内部和外部的咨询监督和年度审查的计划。博士和/或医学博士博士后学员在培训期间培养了显著的独立性。在撰写赠款和职业发展方面提供小组和个人辅导。博士前实习生（包括MD-PhD学生）在SOM的生物医学研究生组的研究生组之一注册，或在SEAS（生物工程，化学/生物分子工程或材料科学工程）或SAS（物理，数学）的选择研究生组。他们完成心血管相关工程课程，作为个人研究生团体要求的一部分或补充。需要参加跨学科研讨会系列和双周跨学科粉笔谈话系列，以及持续的RCR培训。为培训计划量身定制的研究研讨会提供了额外的演讲机会。10-年度计划指标：（36名前博士; 34名博士后）。在26名已毕业的Predocs中（平均5.2年），10名正在接受博士后培训，16名在教师职位（8）或科学工作（8）。其余的（10）仍在训练中。在完成支持的24名博士后中，17名（71%）被招聘到学术职位，6名（25%）被招聘到私营部门科学相关的工作，还有一名正在休探亲假。其余的（10）仍在训练中。受训人员撰写了323篇经同行审查的论文（迄今已被引用14 560次）。 (End摘要）

DESCRIPTION (provided by applicant): This competing renewal HL07954 "Multidisciplinary Training in Cardiovascular Biology" is the principal NIH training grant integrating research between Penn's Schools of Medicine (SOM), Engineering (SEAS) and Arts and Sciences (SAS). We request continuing support of 6 pre- and 6 postdoctoral trainees in multidisciplinary cardiovascular pathophysiology with emphasis on integrated biomedicine - physical/ quantitative/ engineering sciences. Thirty two faculty mentors are distributed across Penn's SOM, Childrens Hospital of Philadelphia, SEAS, and SAS (Physics; Math) departments, Institutes and Centers. The proposal addresses NHLBI multidisciplinary training priorities in 5 key areas by ensuring (i) training breadth and depth through multidisciplinary cardiovascular research integrated across a full spectrum of scales from the molecular to in vivo, (ii) Addition o faculty to ensure training in new and evolving research areas including the development of new courses, (iii) A formalized individual mentorship plan required of each Mentor/ Trainee pairing, (iv) Workforce retention to academic or science-based private-sector positions (for Postdocs), and postdoctoral positions (for Predocs) with attention to diversity, and (v) A translational infrastructure that embraces basic translational potential scientists and Clinical Fellow representation. To sustain a vigorous program, Predocs and Postdocs will receive two and three years support respectively. Trainees are selected in competitive review by an inter-School Steering Committee representative of the interdisciplinary nature of the program. Trainees are selected on the basis of academic record, research potential, and commitment to interdisciplinary cardiovascular biology. There is internal and external advisory oversight and annual review of the program. PhD and/or MD Postdoctoral trainees develop significant independence during their training period. Both group and individual mentorship in grant-writing and career development are provided. Predoctoral trainees (including MD-PhD students) are registered in one of the graduate groups of the Biomedical Graduate Group in the SOM or in select Graduate Groups of SEAS (Bioengineering, Chemical/Biomolecular Engineering, or Materials Science Engineering) or SAS (Physics, Math). They complete courses in cardiovascular-related engineering as part of, or in addition to, individual graduate group requirements. Participation in an Interdisciplinary Seminar Series and a biweekly Interdisciplinary Chalk Talk series is required, as is continuous RCR training. Research Symposia tailored to the training program provide additional presentation opportunities. 10-year program metrics: (36 predocs; 34 postdocs). Of 26 Predocs who have graduated (mean 5.2 yrs) 10 are in postdoctoral training, and 16 are in faculty positions (8) or science jobs (8). The balance (10) are still in training. Of 24 Postdocs who have completed support, 17 (71%) were recruited to academic positions, 6 (25%) to private sector science-related jobs, and one is on family leave. The balance (10) are still in training. Trainees authored 323 peer-reviewed papers (14,560 citations to date). (End of Abstract)