Multidisciplinary Training in Cardiovascular Biology

描述（由申请人提供）：这项竞争更新HL07954“心血管生物学多学科培训”是NIH的主要培训资助，整合了宾夕法尼亚大学医学院（SOM），工程系（SEAS）和文理学院（SAS）之间的研究。我们要求继续支持6名多学科心血管病理生理学的博士生，重点是综合生物医学-物理/定量/工程科学。32名教师导师分布在宾夕法尼亚大学的SOM、费城儿童医院、SEAS和SAS（物理、数学）系、研究所和中心。该提案解决了NHLBI在5个关键领域的多学科培训重点，通过确保(i)通过从分子到体内的全范围多学科心血管研究整合培训的广度和深度，（ii）增加教师以确保在新的和不断发展的研究领域进行培训，包括开发新课程，（iii）每个导师/学员结对需要一个正式的个人指导计划。（iv）将劳动力保留到以学术或科学为基础的私营部门职位（博士后）和博士后职位（pre - docs），并注意多样性；(v)一个包含基本转化潜力科学家和临床研究员代表的转化基础设施。为了维持一个有活力的项目，博士和博士后将分别获得两年和三年的支持。学员由代表该计划跨学科性质的校际指导委员会在竞争性审查中选出。学员是根据学术成绩、研究潜力和对跨学科心血管生物学的承诺来选择的。该计划有内部和外部的咨询监督和年度审查。博士和/或医学博士博士后学员在他们的培训期间发展了显著的独立性。在助学金写作和职业发展方面提供小组和个人指导。博士预科学员（包括医学博士研究生）在SOM生物医学研究生组的一个研究生组注册，或在SEAS（生物工程、化学/生物分子工程或材料科学工程）或SAS（物理、数学）的研究生组注册。他们完成心血管相关工程课程，作为个别研究生组要求的一部分或附加要求。需要参加跨学科研讨会系列和两周一次的跨学科粉笔讲座系列，以及持续的RCR培训。为培训计划量身定制的研究专题讨论会提供了额外的演讲机会。10年项目指标：（36名博士；34名博士后）。在26名毕业的predoc（平均5.2年）中，有10人在接受博士后培训，16人担任教职（8人）或科学工作（8人）。其余（10）人仍在训练中。在完成支持的24名博士后中，17名（71%）被招聘到学术职位，6名（25%）被招聘到私营部门的科学相关工作，1名正在休探亲假。其余（10）人仍在训练中。学员撰写了323篇同行评审论文（迄今为止引用14,560次）。（摘要结束）

DESCRIPTION (provided by applicant): This competing renewal HL07954 "Multidisciplinary Training in Cardiovascular Biology" is the principal NIH training grant integrating research between Penn's Schools of Medicine (SOM), Engineering (SEAS) and Arts and Sciences (SAS). We request continuing support of 6 pre- and 6 postdoctoral trainees in multidisciplinary cardiovascular pathophysiology with emphasis on integrated biomedicine - physical/ quantitative/ engineering sciences. Thirty two faculty mentors are distributed across Penn's SOM, Childrens Hospital of Philadelphia, SEAS, and SAS (Physics; Math) departments, Institutes and Centers. The proposal addresses NHLBI multidisciplinary training priorities in 5 key areas by ensuring (i) training breadth and depth through multidisciplinary cardiovascular research integrated across a full spectrum of scales from the molecular to in vivo, (ii) Addition o faculty to ensure training in new and evolving research areas including the development of new courses, (iii) A formalized individual mentorship plan required of each Mentor/ Trainee pairing, (iv) Workforce retention to academic or science-based private-sector positions (for Postdocs), and postdoctoral positions (for Predocs) with attention to diversity, and (v) A translational infrastructure that embraces basic translational potential scientists and Clinical Fellow representation. To sustain a vigorous program, Predocs and Postdocs will receive two and three years support respectively. Trainees are selected in competitive review by an inter-School Steering Committee representative of the interdisciplinary nature of the program. Trainees are selected on the basis of academic record, research potential, and commitment to interdisciplinary cardiovascular biology. There is internal and external advisory oversight and annual review of the program. PhD and/or MD Postdoctoral trainees develop significant independence during their training period. Both group and individual mentorship in grant-writing and career development are provided. Predoctoral trainees (including MD-PhD students) are registered in one of the graduate groups of the Biomedical Graduate Group in the SOM or in select Graduate Groups of SEAS (Bioengineering, Chemical/Biomolecular Engineering, or Materials Science Engineering) or SAS (Physics, Math). They complete courses in cardiovascular-related engineering as part of, or in addition to, individual graduate group requirements. Participation in an Interdisciplinary Seminar Series and a biweekly Interdisciplinary Chalk Talk series is required, as is continuous RCR training. Research Symposia tailored to the training program provide additional presentation opportunities. 10-year program metrics: (36 predocs; 34 postdocs). Of 26 Predocs who have graduated (mean 5.2 yrs) 10 are in postdoctoral training, and 16 are in faculty positions (8) or science jobs (8). The balance (10) are still in training. Of 24 Postdocs who have completed support, 17 (71%) were recruited to academic positions, 6 (25%) to private sector science-related jobs, and one is on family leave. The balance (10) are still in training. Trainees authored 323 peer-reviewed papers (14,560 citations to date). (End of Abstract)