INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY (IPCS)

国际化学品安全方案（化学品安全方案）成立于1980年，旨在以科学为基础，应对全球对环境污染物对人类健康和环境构成的潜在危险的关切。 化学品安全方案是世界卫生组织（卫生组织）、国际劳工组织和联合国环境规划署的一个合作项目。 国际化学品安全方案的主要目标（与本协定有关）包括：（1）在国际和国家组织之间协调化学品安全问题;（2）对化学品构成的风险进行以科学为基础的国际评估;（3）就改进风险评估的科学基础所需的方法制定国际共识文件;（4）处理全球新出现的环境健康问题。 国际化学品安全方案由卫生组织管理，在日内瓦卫生组织总部和北卡罗来纳州三角研究园NIEHS园区的区域间研究股派驻了少量核心工作人员。 化学品安全方案通过来自33个国家70多个参与机构的国际科学专家组成的广泛网络完成其大部分工作。NIEHS（校内和校外科学家）在国际化学品安全方案的许多活动中发挥着重要的领导作用。 本提案的目的是为下列相互关联的全球环境问题提供一个及时的、具有科学依据的知识基础和可靠的评估：1）干扰内分泌的化学品; 2）环境与儿童健康; 3）基因与环境的相互作用; 4）神经毒性; 5）生殖毒理学; 6）生物标志物; 7）混合物; 8）促进国际合作研究。 实现这些目标将产生各国将基础研究成果转化为全球公共卫生促进和预防做法所需的数据。

The International Programme on Chemical Safety (IPCS) was established in 1980 to provide a science-based response to global concerns about the potential dangers posed by environmental contaminants to human health and the environment. IPCS is a cooperative venture of the World Health Organization (WHO), the International Labour Organization and the United Nations Environment Programme. The major goals of IPCS (relevant to this Agreement) include 1) the coordination of chemical safety issues among international and national organizations; 2) the preparation of science-based international assessments of the risks posed by chemicals; 3) the development of international consensus documents on methodologies needed to improve the scientific basis for risk assessment; and 4) to address global emerging environmental health issues. IPCS is managed by WHO, and has a small core staff stationed at WHO Headquarters in Geneva and at the Interregional Research Unit (IRRU) on the NIEHS campus in Research Triangle Park, N.C. IPCS accomplishes much of its work through a broad network of international scientific experts from over 70 participating institutions in 33 countries. NIEHS (intramural and extramural scientists) play a significant leadership role for many IPCS activities. The aims of this proposal are to provide a timely, scientifically sound knowledge base and credible assessments for the following interrelated global environmental issues: 1) endocrine-disrupting chemicals; 2) environment and children's health; 3) gene-environment interactions; 4) neurotoxicity; 5) reproductive toxicology; 6) biomarkers; 7) mixtures; 8) international collaborative research promotion. Implementation of these aims will generate data needed for countries to translate basic research findings into global public health promotion and prevention practices.