Center for Design:Biomimetic Nanoconductors (RMI)

设计中心：仿生纳米导体（RMI）

• 批准号: 6930727
• 负责人: ERIC G JAKOBSSON
• 金额: $ 6.61万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2005-07-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930727
• 关键词: biomimetics; computer simulation; ion transport; membrane channels; membrane transport proteins; nanotechnology; protein structure function

The mission of the Center is to establish practical design principles and create a design system for nanoscale ionic conductors. The work of the Center will also enhance our understanding of biological ion transport at the molecular level. The work of the Center will be informed by an understanding of four major bodies of knowledge: i) Membrane biology and biophysics, ii) Physical chemistry on the nanoscale and sub-nanoscale, iii) Principles of device engineering, iv) Nanofabrication and synthesis In a larger context the mission of the Center is to contribute to the ability of nanoscience and nanotechnology to serve biomedical research and medical diagnosis and treatment through the fabrication of sensors and devices on the nanoscale that will provide much more fine-grained information about biological systems and ability to intervene in biological systems than has hitherto been available. Our Center will make its contribution to that technology by providing design tools and actual collaboration in the ion conduction components of biomedical nanotechnology, both from the perspective of how to design ion conduction components in nanodevices and also from the perspective of understanding details of biological ion conduction. The Center has four specific aims:1) We will aim to move our current understanding of biological channels and transporters from the present level of grasping the essence of structure-function relationships to the more extreme level of being able to physically model the functioning of channels and transporters at the predictive level of precision essential for engineering design. 2) We will aim to embody the computational methods that we employ and develop into an ion transporter design portal that can serve as a computer-aided-design (CAD) system for nanoconductors. 3) We will aim to combine our knowledge of the physics of biological transport with engineering principles to do computer-aided design of nanoscale ion transporters. 4) We will aim to build working prototypes of designed nanoscale ion transporters.

中心的任务是建立实用的纳米级离子导体的设计原则，并创建一个设计系统。中心的工作也将增强我们对分子水平上生物离子运输的认识。中心的工作将以了解四个主要的知识体系为指导：i)膜生物学和生物物理学，ii)纳米尺度和亚纳米尺度的物理化学，iii)器件工程原理，四)纳米制造和合成在更大的背景下，本中心的使命是通过制造纳米级传感器和设备，促进纳米科学和纳米技术为生物医学研究和医学诊断和治疗服务的能力，这些传感器和设备将提供比迄今为止更多的关于生物系统的细粒度信息和干预生物系统的能力。本中心将从如何设计离子传导的角度出发，为生物医学纳米技术的离子传导组件提供设计工具和实际合作，从而为该技术做出贡献

项目成果

Nonintercalating nanosubstrates create asymmetry between bilayer leaflets.

非干预纳米底物在双层小叶之间产生不对称性。

• DOI: 10.1021/la204623u
• 发表时间: 2012-02-07
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Varma S;Teng M;Scott HL
• 通讯作者: Scott HL

The role of membranes in the organization of HIV-1 Gag p6 and Vpr: p6 shows high affinity for membrane bilayers which substantially increases the interaction between p6 and Vpr.

• DOI: 10.1021/jm901106t
• 发表时间: 2009-11
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: G. Salgado;Alexander Vogel;Rodrigue Marquant;S. Feller;S. Bouaziz;I. Alves