SIMULATION STUDIES OF HETEROGENEOUS MEMBRANES

异质膜的模拟研究

• 批准号: 7601340
• 负责人: ERIC G JAKOBSSON
• 金额: $ 0.03万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601340
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Funding; Goals; Grant; Hybrids; Institution; Lateral; Lipid Bilayers; Lipids; Membrane; Membrane Transport Proteins; Methodology; Microscopic; Property; Research; Research Personnel; Resources; Role playing therapy; Source; Techniques; United States National Institutes of Health; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goals of the proposed research are to utilize large-scale computer simulations to study multi-component lipid bilayers and bilayers containing biologically important molecules. The goal of the simulations is to determine at the atomic level the interactions and mechanisms that underlie observed structural and dynamical properties of membranes. We propose to apply our previously developed hybrid simulation method and other new simulation methodologies to determine those microscopic interactions and the roles played by lipid molecules in the lateral organization of membranes. Subprojects 1-4 below are research efforts that were begun under the previous Allocation, whereas Subproject 5 is a newer effort to consider another type of membrane transporter.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议研究的总体目标是利用大规模 计算机模拟研究多组分脂质双层和双层 含有重要的生物分子模拟的目的是 以确定在原子水平上的相互作用和机制， 是观察到的膜的结构和动力学性质的基础。我们 建议应用我们以前开发的混合仿真方法， 其他新的模拟方法，以确定这些微观 相互作用和脂质分子在横向 膜的组织。以下分项目1-4是研究工作， 在以前的拨款下开始，而子项目5是一个较新的项目。 努力考虑另一种类型的膜转运蛋白。