NATIONAL CENTER FOR DESIGN:BIOMIMETIC NANOCONDUCTOR(RMI)

国家设计中心：仿生纳米导体（RMI）

• 批准号: 7498982
• 负责人: ERIC G JAKOBSSON
• 金额: $ 128.25万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498982
• 关键词: Accounting; Affect; Automobile Driving; Behavior; Binding; Biological; Biological Assay; Biomimetics; Carrier Proteins; Categories; Cells; Charge; Chemistry; Class; Code; Compatible; Coupled; Coupling; DNA Sequence Rearrangement; Data; Depth; Development; Devices; Disease; Electrons; Environment; Equilibrium; Evaluation; Event; Experimental Models; Free Energy; Generations; Hydration status; Ion Channel; Ion Transport; Ions; Left; Life; Lipids; Mechanics; Membrane; Metals; Methods; Modeling; Molecular; Object Attachment; Organelles; Osmotic Pressure; Physiological Processes; Power Sources; Probability; Process; Property; Proteins; Protons; Pump; Range; Reaction; Relative (related person); Research; Role; Sampling; Scheme; Signal Transduction; Silicates; Simulate; Site; Standards of Weights and Measures; Statistical Models; Structure; Structure-Activity Relationship; Surface; System; Testing; Theoretical model; Thermodynamics; Transducers; Variant; Viral Genome; Water; Work; abstracting; aqueous; chemical bond; design; environmental change; functional restoration; insight; ionization; knowledge base; molecular dynamics; mutant; nanoconductor; nanomedicine; nanopore; nanoscale; neglect; novel strategies; protonation; quantum; research study; sensor; simulation; size

DESCRIPTION (application abstract) The theme of the proposed Nanomedicine Development Center is design of biomimetic nanoconductors and devices utilizing nanoconductors. The model theoretical systems will be native and mutant biological ion channels and other ion transport proteins and synthetic channels, and heterogenous membranes containing channels and transporters. The model experimental systems will be decorated nanopores in silicate wafers or other substrates, and ion channels and transporters with lipid surround inserted in arrays of nanopores. In some cases the experiments will be designed to assay the properties of the channels and transporters. In other cases, the experiments will be designed to explore the emergent properties of heterogeneous arrays of transporters as they apply to major roles of ion transport in biological systems: a) Electrical and electrochemical signaling b) generation of osmotic pressures and flows c) generation of electrical power. d) Energy transduction At the most applied level, the experiments now planned will be aimed directly at the design of a class of devices for generating electric power, the biobattery. General relevance: It appears that every living cell has membrane ion transporters, and some viral genomes code for them as well. They are universally implicated in regulating and driving water balance and osmotic flow, signaling, generation of electrical currents, and transduction of energy at the level of cells, organelles, and molecules. Thus deeper understandings of the molecular mechanisms of ion transport, and of the emergent properties from the interactions of ion transporters, have broad relevance to understanding a wide range of physiological processes. These understandings will yield insight into disease echanisms and targeting strategies against diseases, and also form the knowledge base for design of medically useful biomimetic bio-compatible devices. The broad categories of such devices that we reckon can be constructed using nanoconductor components are: sensors, power sources, energy transducers, and osmotic pumps. The devices can be any size from nanoscale up. They can be utilized for either research or therapy in any situation in which miniaturizability, biocompability, efficiency, and bio-drivability, as described above, are significant assets.

描述（应用摘要） 纳米医学发展中心的主题是设计仿生纳米导体和利用纳米导体的设备。模型理论系统将是天然的和突变的生物离子通道和其他离子转运蛋白和合成通道，以及含有通道和转运蛋白的异质性膜。该模型实验系统将在硅酸盐晶片或其他基底上装饰纳米孔，并在纳米孔阵列中插入具有脂质包围的离子通道和转运体。在某些情况下，实验将被设计为测定通道和转运蛋白的性质。在其他情况下，实验将被设计为探索转运蛋白的异质阵列的涌现特性，因为它们适用于生物系统中离子转运的主要作用： a）电气和电化学信号 B）产生渗透压和渗透流 （三）发电。 d）能量转换 在最实用的层面上，目前计划的实验将直接针对一类发电设备的设计，即生物电池。 一般相关性：似乎每个活细胞都有膜离子转运蛋白，一些病毒基因组也为它们编码。它们普遍参与调节和驱动水平衡和渗透流，信号传导，电流产生以及细胞，细胞器和分子水平的能量转导。因此，更深入地了解离子转运的分子机制以及离子转运蛋白相互作用产生的新特性，对于理解广泛的生理过程具有广泛的相关性。这些理解将产生深入了解疾病的机制和针对疾病的靶向策略，也形成了知识基础，设计医学上有用的仿生生物相容性设备。我们认为可以使用纳米导体组件构建的此类设备的大类是：传感器，电源，能量转换器和渗透泵。这些器件可以是纳米级以上的任何尺寸。它们可用于任何情况下的研究或治疗，其中如上所述的可生物降解性、生物相容性、效率和生物可驱动性是重要的资产。