NATIONAL CENTER FOR DESIGN:BIOMIMETIC NANOCONDUCTOR(RMI)

国家设计中心：仿生纳米导体（RMI）

• 批准号: 7098590
• 负责人: ERIC G JAKOBSSON
• 金额: $ 146.19万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7098590
• 关键词: biomimetics; computer simulation; ion transport; membrane channels; membrane transport proteins; nanotechnology; protein structure function

DESCRIPTION (application abstract) The theme of the proposed Nanomedicine Development Center is design of biomimetic nanoconductors and devices utilizing nanoconductors. The model theoretical systems will be native and mutant biological ion channels and other ion transport proteins and synthetic channels, and heterogenous membranes containing channels and transporters. The model experimental systems will be decorated nanopores in silicate wafers or other substrates, and ion channels and transporters with lipid surround inserted in arrays of nanopores. In some cases the experiments will be designed to assay the properties of the channels and transporters. In other cases, the experiments will be designed to explore the emergent properties of heterogeneous arrays of transporters as they apply to major roles of ion transport in biological systems: a) Electrical and electrochemical signaling b) generation of osmotic pressures and flows c) generation of electrical power. d) Energy transduction At the most applied level, the experiments now planned will be aimed directly at the design of a class of devices for generating electric power, the biobattery. General relevance: It appears that every living cell has membrane ion transporters, and some viral genomes code for them as well. They are universally implicated in regulating and driving water balance and osmotic flow, signaling, generation of electrical currents, and transduction of energy at the level of cells, organelles, and molecules. Thus deeper understandings of the molecular mechanisms of ion transport, and of the emergent properties from the interactions of ion transporters, have broad relevance to understanding a wide range of physiological processes. These understandings will yield insight into disease echanisms and targeting strategies against diseases, and also form the knowledge base for design of medically useful biomimetic bio-compatible devices. The broad categories of such devices that we reckon can be constructed using nanoconductor components are: sensors, power sources, energy transducers, and osmotic pumps. The devices can be any size from nanoscale up. They can be utilized for either research or therapy in any situation in which miniaturizability, biocompability, efficiency, and bio-drivability, as described above, are significant assets.

说明(应用程序摘要) 拟议的纳米医学开发中心的主题是设计仿生纳米导体和利用纳米导体的设备。该模型的理论体系将包括天然和突变的生物离子通道和其他离子转运蛋白和合成通道，以及含有通道和转运蛋白的异质膜。模型实验系统将在硅酸盐晶片或其他基质中装饰纳米孔，并在纳米孔阵列中插入带有脂质包围的离子通道和转运体。在某些情况下，这些实验将被设计来测试通道和转运体的特性。在其他情况下，这些实验将被设计用来探索不同种类的转运体阵列的紧急特性，因为它们适用于生物系统中离子传输的主要角色： A)电信号和电化学信号 B)产生渗透压和渗透流量 C)发电。 D)能量传递 在最实用的层面上，现在计划的实验将直接针对一类发电设备的设计，即生物养殖场。一般相关性：似乎每个活细胞都有膜离子转运体，一些病毒基因组也为它们编码。在细胞、细胞器和分子水平上，它们普遍参与调节和驱动水平衡和渗透流、信号、电流的产生和能量的传递。因此，深入了解离子传输的分子机制，以及离子转运体相互作用产生的特性，对于理解广泛的生理过程具有广泛的相关性。这些理解将有助于深入了解疾病的机制和针对疾病的靶向策略，并为设计具有医学用途的仿生生物兼容设备提供知识基础。我们认为可以使用纳米导体组件构建的此类设备的大类有：传感器、电源、能量转换器和渗透泵。这些设备可以是任何尺寸，从纳米级到纳米级。如上所述，在小型化、生物相容性、效率和生物可驱动性是重要资产的任何情况下，它们既可用于研究，也可用于治疗。