Clinical MRI of Peripheral Arterial Disease

周围动脉疾病的临床 MRI

• 批准号: 6803969
• 负责人: DWIGHT NISHIMURA
• 金额: $ 47.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-27 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803969
• 关键词: artery; artery occlusion; bioimaging /biomedical imaging; blood flow measurement; clinical research; computer data analysis; computer program /software; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; dogs; fluorimetry; human subject; image enhancement; image processing; ischemia; limbs; magnetic resonance imaging; musculoskeletal circulation; noninvasive diagnosis; outcomes research; peripheral blood vessel disorder; skin circulation; technology /technique development; three dimensional imaging /topography; venous thrombosis

DESCRIPTION (provided by applicant): There is a need for better noninvasive imaging methods to detect and assess the nature of peripheral arterial disease for therapeutic planning and monitoring. With the emergence of angiogenetic agents and stem-cell transplantation as potentially new therapeutic options for patients with severe lower extremity ischemia, the importance of such noninvasive assessment methods is growing. The aim of this research program is to develop and evaluate new magnetic resonance (MR) imaging methods aimed at enabling improved detection and characterization of patients with peripheral arterial disease. These new MR imaging tools include those to assess 1) lower extremity vessel anatomy, 2) global and regional perfusion, and 3) skin anatomy and physiology. The general hypothesis is that a new noninvasive and objective set of tools to characterize vascular anatomy, deep tissue and superficial skin perfusion, and skin morphology will provide a less morbid and more accurate predictor of therapy and outcome in patients with severe peripheral arterial disease. The research design will consist of technical studies leading to clinical studies evaluating the efficacy of these methods. The technical studies will be directed at developing and optimizing the various MR sequences and validating them under controlled situations. The clinical studies will be performed on patients with critical limb ischemia and skin pathology.

描述(由申请人提供)：需要更好的非侵入性成像方法来检测和评估外周动脉疾病的性质，以便进行治疗计划和监测。随着血管生成剂和干细胞移植作为治疗严重肢体缺血患者潜在的新的治疗选择的出现，这种非侵入性评估方法的重要性越来越大。这项研究计划的目的是开发和评估新的磁共振(MR)成像方法，旨在改善对周围动脉疾病患者的检测和特征。这些新的磁共振成像工具包括评估1)下肢血管解剖，2)全局和局部灌注，以及3)皮肤解剖和生理学。一般的假设是，一套新的非侵入性和客观的工具来表征血管解剖、深层组织和浅层皮肤灌注以及皮肤形态，将为严重外周动脉疾病患者的治疗和结果提供更少的病态和更准确的预测指标。研究设计将包括导致临床研究评估这些方法的有效性的技术研究。技术研究将旨在开发和优化各种磁共振序列，并在受控情况下对其进行验证。临床研究将在患有严重肢体缺血和皮肤病理的患者身上进行。