Clinical MRI of Peripheral Arterial Disease

周围动脉疾病的临床 MRI

• 批准号: 7984076
• 负责人: DWIGHT NISHIMURA
• 金额: $ 40万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-27 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7984076
• 关键词: Anatomy; Area; Blood Vessels; Clinical; Contrast Media; Development; Diagnosis; Disease; Evaluation; Evaluation Studies; Growth Factor; High Prevalence; Image; Injection of therapeutic agent; Ischemia; Lead; Leg; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Measurement; Methods; Modality; Monitor; Noise; Pathology; Patient Monitoring; Patients; Perfusion; Peripheral arterial disease; Regional Perfusion; Research; Resolution; Sensitivity and Specificity; Signal Transduction; Skin; Source; Speed; Stem cell transplant; Stem cells; Techniques; Testing; Therapeutic; Time; Tissues; United States; Work; blood perfusion; design; disability; flexibility; imaging modality; improved; method development; operation; programs; public health relevance; response; stem

DESCRIPTION (provided by applicant): Peripheral arterial disease (PAD) is a major cause of disability in the United States. Despite the high prevalence of this disease, conventional evaluation of patients with this condition often lacks the sensitivity and specificity needed to make therapeutic decisions or to monitor potentially new treatment options such as stem-cell transplantation and angiogenic agents. The aims of this project are to develop and evaluate new magnetic resonance imaging (MRI) methods for the improved assessment of peripheral arterial disease (PAD). The potential impact of this work is significant as it could lead to a new and improved noninvasive examination of this disease. This project will focus on the following areas: 1) three-dimensional (3D) blood- vessel imaging of the leg without the need for contrast agent injection, and 2) time-resolved 3D dynamic contrast-enhanced imaging of the lower leg for regional blood perfusion information. Substantial technical studies in these areas to develop and optimize the MRI methods will be followed by a pilot evaluative study on patients with PAD. PUBLIC HEALTH RELEVANCE: There is a need for new and improved methods to assess peripheral arterial disease (PAD), a major source of disability in the United States. Magnetic resonance imaging (MRI) is a flexible and noninvasive modality that offers the potential to provide information to help diagnose and monitor patients with this disease. This research will develop, optimize, and evaluate new MRI methods designed for patients with PAD.

描述（由申请人提供）： 外周动脉疾病（PAD）是美国残疾的主要原因。尽管这种疾病的患病率很高，但对这种疾病患者的常规评估往往缺乏做出治疗决策或监测潜在的新治疗方案（例如干细胞移植和血管生成剂）所需的敏感性和特异性。该项目的目的是开发和评估新的磁共振成像 (MRI) 方法，以改进外周动脉疾病 (PAD) 的评估。这项工作的潜在影响是重大的，因为它可能会导致对该疾病进行新的和改进的无创检查。该项目将重点关注以下领域：1）无需注射造影剂的腿部三维（3D）血管成像，2）小腿的时间分辨3D动态对比增强成像，以获取区域血液灌注信息。在这些领域进行大量技术研究以开发和优化 MRI 方法后，将对 PAD 患者进行试点评估研究。 公共卫生相关性： 需要新的和改进的方法来评估外周动脉疾病（PAD），这是美国残疾的主要根源。磁共振成像 (MRI) 是一种灵活的非侵入性检查方式，有可能提供信息来帮助诊断和监测患有这种疾病的患者。这项研究将开发、优化和评估专为 PAD 患者设计的新 MRI 方法。