IMPROVED MR PERIPHERAL ANGIOGRAPHY

此应用程序是以前的1 RO1 HL56394的修订版 题为《改进的磁共振血管成像方法》。这个 原来的应用提出了几个新的广阔的发展方向 无创性磁共振血管成像(MRA)方法的研究 颈动脉、肾和外周血管。在这次重新提交中，现在 这项名为“改良的磁共振外周血管造影术”的研究计划聚焦于 关于这些MRA方法的发展、实施和评估 在一个特定的区域--下肢。这一点的重点 将对两种新的MRA方法进行研究：1)一种与流量无关的方法 非常适合产生高对比度的血管造影法 慢流区域中的血管图像，以及2)修改版本的 二维飞行时间血管造影术，它使用放射线k- 空间轨迹，减少脉动伪影，实现更快 成像。这些新方法解决了流伪影的问题， 流动缓慢、成像时间过长和不足的困难 空间分辨率限制了常规方法的有效性 磁共振血管成像方法。这些新方法的初步临床结果充分 展示其巨大的潜力。一段技术上的时期 在开发和优化之后，将进行比较研究 将我们的MRA方法与常规MRA和x射线血管造影术进行比较 在患有外周动脉疾病的患者中。这些新方法很有希望 提供改进的动脉硬化症检测和表征 腿部疾病。

This application is an amended version of 1 RO1 HL56394, previously titled "Improved Methods for Magnetic Resonance Angiography." The original application had proposed the broad development of several new methods for noninvasive magnetic resonance angiography (MRA) of carotid, renal, and peripheral vessels. In this resubmission, now titled "Improved MR Peripheral Angiography," the research plan focuses on the development, implementation, and evaluation of these MRA methods in a specific region-the lower extremities. The emphasis of this investigation will be on two novel MRA methods: 1) a flow-independent angiographic method that is well-suited for producing high-contrast vessel images in regions of slow flow, and 2) a modified version of two-dimensional time-of-flight angiography that uses a radial-line k- space trajectory to reduce pulsatility artifacts and achieve faster imaging. These new methods address the problems of flow artifacts, difficulties with slow flow, excessive imaging time, and inadequate spatial resolution which have limited the effectiveness of conventional MRA methods. Preliminary clinical results with these new methods amply demonstrate their substantial potential. A period of technical development and optimization will be followed by a comparative study of our MRA methods with conventional MRA and x-ray contrast angiography in patients with peripheral arterial disease. These new methods promise to provide improved detection and characterization of arteriosclerotic disease in the lower extremities.