Coronary Magnetic Resonance Angiography

项目摘要 这个项目的目标是健壮的、无创的磁共振(Mr)。 人体冠状动脉近端的成像。磁共振是一种动态的情态 这为处理涉及的注意事项提供了极大的灵活性 冠状动脉成像，包括分辨率(空间和时间)和运动。 MR硬件、脉冲序列和数据处理方面的改进 算法导致了冠状动脉磁共振血管成像的进步 (CMRA)。然而，在图像质量和一致性方面的进一步改进是 需要将CMRA提高到临床实用的水平。 拟议的研究计划涉及开发和评估新的 方法：CMRA。关键组件包括用于FAST的新型3D圆锥体轨迹 全心全意成像，以及基于高质量3D图像的导航器(INAV) 心跳，用于监测心脏每个区域的运动。与.相比 传统的CMRA方法，非笛卡尔3D圆锥扫描提供了更高的 扫描效率和改进的心脏运动性能。与.相比 传统的导航方法，3D iNAV提供了更多的信息 关于扫描过程中的心脏运动。CMRA的主要增强功能将包括 在这个项目中研究的，包括更高分辨率和更健壮的那些 运动检测-补偿。在经历了一段时间的技术发展和 初步评价，优化的CMRA方法与传统方法的比较研究 X射线血管造影术(狭窄和血流储备分数测量)将采取 适用于疑似冠心病患者。

Project Abstract The goal of this project is the robust, noninvasive magnetic resonance (MR) imaging of the proximal coronary arteries in humans. MR is a dynamic modality that offers enormous flexibility to deal with the considerations involved in coronary artery imaging, including resolution (spatial and temporal) and motion. Improvements in MR hardware, pulse sequences, and data processing algorithms have led to advances in coronary magnetic resonance angiography (CMRA). However, further improvements in image quality and consistency are needed to raise CMRA to the level of clinical utility. The proposed research plan involves the development and evaluation of new methods for CMRA. Key components include a novel 3D cones trajectory for fast whole-heart imaging, and high-quality 3D image-based navigators (iNAVs) every heartbeat for monitoring motion in every region of the heart. Compared to conventional CMRA methods, non-Cartesian 3D cones scanning offers higher scan efficiency and improved motion performance in the heart. Compared to conventional navigator methods, 3D iNAVs provide much greater information about heart motion during the scan. Major enhancements to CMRA will be investigated in this project, including those for higher resolution and more robust motion detection-compensation. Following a period of technical development and preliminary evaluation, a comparative study of the optimized CMRA method with x-ray angiography (stenosis and fractional flow reserve measurements) will take place on patients with suspected coronary artery disease.