Coronary Magnetic Resonance Angiography

项目摘要 该项目的目标是强大的，非侵入性的磁共振（MR） 人体近端冠状动脉成像。MR是一种动态模态 这提供了巨大的灵活性，以处理涉及的考虑， 冠状动脉成像，包括分辨率（空间和时间）和运动。 MR硬件、脉冲序列和数据处理的改进 算法导致了冠状动脉磁共振血管造影术的进步 （CMRA）。然而，图像质量和一致性的进一步改进是必要的。 需要将CMRA提高到临床实用水平。 拟议的研究计划涉及新技术的开发和评估 CMRA的方法。关键组件包括一种新颖的3D锥体轨迹， 全心脏成像和高质量的3D图像导航仪（iNAV）， 用于监测心脏每个区域的运动。相比 传统的CMRA方法，非笛卡尔3D圆锥扫描提供更高的 扫描效率和改善的心脏运动性能。相比 传统的导航方法，3D iNAV提供了更多的信息 扫描时的心脏运动CMRA的主要增强功能包括 研究在这个项目中，包括那些更高的分辨率和更强大的 运动检测补偿。经过一段时间的技术发展和 初步评价，优化CMRA方法的比较研究， X射线血管造影（狭窄和血流储备分数测量）将进行 冠状动脉疾病的患者。

Project Abstract The goal of this project is the robust, noninvasive magnetic resonance (MR) imaging of the proximal coronary arteries in humans. MR is a dynamic modality that offers enormous flexibility to deal with the considerations involved in coronary artery imaging, including resolution (spatial and temporal) and motion. Improvements in MR hardware, pulse sequences, and data processing algorithms have led to advances in coronary magnetic resonance angiography (CMRA). However, further improvements in image quality and consistency are needed to raise CMRA to the level of clinical utility. The proposed research plan involves the development and evaluation of new methods for CMRA. Key components include a novel 3D cones trajectory for fast whole-heart imaging, and high-quality 3D image-based navigators (iNAVs) every heartbeat for monitoring motion in every region of the heart. Compared to conventional CMRA methods, non-Cartesian 3D cones scanning offers higher scan efficiency and improved motion performance in the heart. Compared to conventional navigator methods, 3D iNAVs provide much greater information about heart motion during the scan. Major enhancements to CMRA will be investigated in this project, including those for higher resolution and more robust motion detection-compensation. Following a period of technical development and preliminary evaluation, a comparative study of the optimized CMRA method with x-ray angiography (stenosis and fractional flow reserve measurements) will take place on patients with suspected coronary artery disease.