Coronary Magnetic Resonance Angiography

冠状动脉磁共振血管造影

• 批准号: 8863658
• 负责人: DWIGHT NISHIMURA
• 金额: $ 39.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8863658
• 关键词: Address; Adoption; Age; Algorithms; Anatomy; Angiography; Arteries; Blood Vessels; Breathing; Calcium; Cardiac; Cause of Death; Cicatrix; Clinical; Comparative Study; Cone; Coronary; Coronary Arteriosclerosis; Coronary artery; Data; Detection; Development; Diagnostic; Disease; Evaluation; Financial compensation; Goals; Gold; Healthcare; Heart; Human; Image; Lead; Left; Lesion; Magnetic Resonance; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Medical Imaging; Methods; Modality; Monitor; Motion; Myocardial; Myocardial Ischemia; Myocardial perfusion; Noise; Painless; Patients; Performance; Physiologic pulse; Process; Property; Radial; Radiation; Research; Resolution; Resources; Scanning; Signal Transduction; Stenosis; Technology; Three-Dimensional Image; Three-Dimensional Imaging; United States; base; cardiovascular imaging; cardiovascular visualization; computerized data processing; contrast imaging; coronary computed tomography angiography; data acquisition; design; experience; flexibility; heart imaging; heart motion; imaging modality; improved; non-invasive imaging; novel; programs; public health relevance; respiratory; temporal measurement

 DESCRIPTION (provided by applicant): The goal of this project is the robust, noninvasive magnetic resonance (MR) imaging of the proximal coronary arteries in humans. MR is a dynamic modality that offers enormous flexibility to deal with the considerations involved in coronary artery imaging, including resolution (spatial and temporal) and motion. Improvements in MR hardware, pulse sequences, and data processing algorithms have led to advances in coronary magnetic resonance angiography (CMRA). However, further improvements in image quality and consistency are needed to raise CMRA to the level of clinical utility. The proposed research plan involves the development and evaluation of new methods for CMRA. Key components of the plan include a novel 3D cones trajectory for fast whole-heart imaging, and high-quality 3D image-based navigators (iNAVs) every heartbeat for motion monitoring. Compared to conventional CMRA methods, non-Cartesian 3D cones scanning offers higher scan efficiency and improved motion performance in the heart. Compared to conventional navigator methods, 3D iNAVs provide far more information about heart motion during the scan. Major enhancements to CMRA will be investigated in this project, including those for substantially higher resolution and more robust motion detection-compensation. Following a period of technical development and preliminary evaluation, a comparative study of the optimized CMRA method with x-ray blood vessel imaging will take place on patients with suspected coronary artery disease.