Coronary Magnetic Resonance Angiography

 描述（由申请人提供）：本项目的目标是对人体近端冠状动脉进行稳健的无创磁共振（MR）成像。MR是一种动态模态，可提供极大的灵活性来处理冠状动脉成像中涉及的考虑因素，包括分辨率（空间和时间）和运动。MR硬件、脉冲序列和数据处理算法的改进导致了冠状动脉磁共振血管造影术（CMRA）的进步。然而，需要进一步改善图像质量和一致性，以提高CMRA的临床实用性水平。拟议的研究计划涉及CMRA新方法的开发和评估。该计划的关键组成部分包括用于快速全心脏成像的新型3D锥体轨迹，以及用于运动监测的每次心跳的高质量3D基于图像的导航器（iNAV）。与传统的CMRA方法相比，非笛卡尔3D锥体扫描提供了更高的扫描效率和改善的心脏运动性能。与传统的导航方法相比，3D iNAV在扫描过程中提供了更多关于心脏运动的信息。本项目将研究CMRA的主要增强功能，包括大幅提高分辨率和更鲁棒的运动检测补偿。经过一段时间的技术开发和初步评估，将对疑似冠状动脉疾病患者进行优化CMRA方法与X射线血管成像的比较研究。

 DESCRIPTION (provided by applicant): The goal of this project is the robust, noninvasive magnetic resonance (MR) imaging of the proximal coronary arteries in humans. MR is a dynamic modality that offers enormous flexibility to deal with the considerations involved in coronary artery imaging, including resolution (spatial and temporal) and motion. Improvements in MR hardware, pulse sequences, and data processing algorithms have led to advances in coronary magnetic resonance angiography (CMRA). However, further improvements in image quality and consistency are needed to raise CMRA to the level of clinical utility. The proposed research plan involves the development and evaluation of new methods for CMRA. Key components of the plan include a novel 3D cones trajectory for fast whole-heart imaging, and high-quality 3D image-based navigators (iNAVs) every heartbeat for motion monitoring. Compared to conventional CMRA methods, non-Cartesian 3D cones scanning offers higher scan efficiency and improved motion performance in the heart. Compared to conventional navigator methods, 3D iNAVs provide far more information about heart motion during the scan. Major enhancements to CMRA will be investigated in this project, including those for substantially higher resolution and more robust motion detection-compensation. Following a period of technical development and preliminary evaluation, a comparative study of the optimized CMRA method with x-ray blood vessel imaging will take place on patients with suspected coronary artery disease.