Clinical MRI of Peripheral Arterial Disease

描述(由申请人提供)： 在美国，外周动脉疾病(PAD)是导致残疾的主要原因。尽管这种疾病的发病率很高，但对这种疾病患者的传统评估往往缺乏做出治疗决定或监测潜在的新治疗方案(如干细胞移植和血管生成剂)所需的敏感性和特异性。本项目的目的是开发和评估新的磁共振成像(MRI)方法，以改进对周围动脉疾病(PAD)的评估。这项工作的潜在影响是重大的，因为它可能导致一种新的、改进的对这种疾病的非侵入性检查。该项目将专注于以下领域：1)不需要注射造影剂的腿部三维(3D)血管成像，以及2)小腿局部血流灌注信息的时间分辨率3D动态对比增强成像。在这些领域进行大量技术研究以开发和优化MRI方法之后，将对PAD患者进行试验性评估研究。 公共卫生相关性： 需要新的和改进的方法来评估外周动脉疾病(PAD)，这是美国残疾的主要来源。磁共振成像(MRI)是一种灵活的、非侵入性的方式，它提供了提供信息以帮助诊断和监测患有这种疾病的患者的潜力。这项研究将开发、优化和评估为PAD患者设计的新的MRI方法。

DESCRIPTION (provided by applicant): Peripheral arterial disease (PAD) is a major cause of disability in the United States. Despite the high prevalence of this disease, conventional evaluation of patients with this condition often lacks the sensitivity and specificity needed to make therapeutic decisions or to monitor potentially new treatment options such as stem-cell transplantation and angiogenic agents. The aims of this project are to develop and evaluate new magnetic resonance imaging (MRI) methods for the improved assessment of peripheral arterial disease (PAD). The potential impact of this work is significant as it could lead to a new and improved noninvasive examination of this disease. This project will focus on the following areas: 1) three-dimensional (3D) blood- vessel imaging of the leg without the need for contrast agent injection, and 2) time-resolved 3D dynamic contrast-enhanced imaging of the lower leg for regional blood perfusion information. Substantial technical studies in these areas to develop and optimize the MRI methods will be followed by a pilot evaluative study on patients with PAD. PUBLIC HEALTH RELEVANCE: There is a need for new and improved methods to assess peripheral arterial disease (PAD), a major source of disability in the United States. Magnetic resonance imaging (MRI) is a flexible and noninvasive modality that offers the potential to provide information to help diagnose and monitor patients with this disease. This research will develop, optimize, and evaluate new MRI methods designed for patients with PAD.