CORE--NOD/SCID MOUSE

该核心单元的功能是协助PPG的研究人员对其载体转导的人细胞进行体内功能评价。这将通过将转导的人造血细胞移植到接受性异种宿主（NOD/SCID或NOD/SCID/β 2/mug-/-）中来实现。该单位将产生并维持足够数量的NOD/SCID或NOD/SCID/β 2/mug-/-小鼠，以满足本PPG研究者的需求，并将负责移植的机制（即，照射，静脉内，或骨髓内注射供体细胞）。此外，该股将进行取样，并至少部分协助评估移植人体细胞命运所需的移植后评价。

The function of this core unit is to assist investigators of this PPG in the in vivo functional evaluation of human cells transduced by their vectors. This will be achieved by using transplantations of transduced human hemopoietic cells into a receptive xenogeneic host (NOD/SCID or NOD/SCID/beta2/mug-/-). The unit will generate and maintain sufficient numbers of NOD/SCID or NOD/SCID/beta2/mug-/- mice, to accommodate the needs of investigators of this PPG, and will be responsible for the mechanics of transplantation (i.e., irradiation, i.v., or intramarrow injection of donor cells). In addition, the unit will undertake the sampling and assist, at least in part, in the post-transplant evaluation required to assess the fate of the transplanted human cells.