CORE--NOD/SCID MOUSE

这个核心单元的功能是协助PPG的研究人员在体内评估由其载体转导的人类细胞的功能。这将通过将转导的人类造血细胞移植到接受性异种宿主(NOD/SCID或NOD/SCID/beta2/mug-/-)来实现。该单位将产生和维持足够数量的NOD/SCID或NOD/SCID/Beta2/MUG-/-小鼠，以满足PPG研究人员的需要，并将负责移植的机制(即照射、静脉注射或骨髓内注射供体细胞)。此外，该股将进行抽样，并至少部分协助评估移植的人类细胞命运所需的移植后评估。

The function of this core unit is to assist investigators of this PPG in the in vivo functional evaluation of human cells transduced by their vectors. This will be achieved by using transplantations of transduced human hemopoietic cells into a receptive xenogeneic host (NOD/SCID or NOD/SCID/beta2/mug-/-). The unit will generate and maintain sufficient numbers of NOD/SCID or NOD/SCID/beta2/mug-/- mice, to accommodate the needs of investigators of this PPG, and will be responsible for the mechanics of transplantation (i.e., irradiation, i.v., or intramarrow injection of donor cells). In addition, the unit will undertake the sampling and assist, at least in part, in the post-transplant evaluation required to assess the fate of the transplanted human cells.