课题基金 / 基金详情

Assessment Of Lymphocytes In Patients With Autoimmune Ly

Assessment Of Lymphocytes In Patients With Autoimmune Ly
自身免疫性 Ly 患者淋巴细胞的评估
批准号:
6675210
负责人:
thomas a fleisher
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

项目摘要

项目成果

thomas a fleisher的其他基金

相关文献

中文摘要
翻译
在扩增双阴性t细胞和b细胞群特征的基础上,对自身免疫性淋巴细胞增生性综合征(ALPS)患者及其大家庭成员进行了广泛的流式细胞术评估。双阴性t细胞已被证明是α - β TcR、CD57+、HLA-DR+和CD45RA+。这项研究已经扩展到更完整地表征双阴性t细胞,包括B220表达和γ - δ TcR t细胞在所有ALPS患者中的表达。此外,我们已经开始扩大B细胞的表征,针对这些患者使用CD27和B220评估记忆B细胞。在ALPS患者的B细胞中观察到的结果与另一项针对人淋巴细胞B220表达评估的活性方案直接相关。我们已经确定的CD4/CD25 T细胞的相对缺乏导致了针对该T细胞亚群的功能研究的开始,以评估免疫表型发现是否代表免疫调节性T细胞的功能缺陷,从而可以解释ALPS 1a型家庭的基因型表型差异。
英文摘要
An extensive flow cytometric evaluation continues of patients with autoimmune lymphoproliferative syndrome (ALPS) and their extended family members, on the basis of characterization of the expanded double-negative T-cell and B-cell populations. Double-negative T-cells have been demonstrated to be alpha beta TcR, CD57+, HLA-DR+, and CD45RA+. This study has been extended to characterize the double-negative T-cells more completely including B220 expression and gamma-delta TcR T-cells in all ALPS patients. In addition, we have initiated expanded characterization of the B cells, directed at memory B cells using CD27 and B220 assessment in these patients. The observations in the B cells of ALPS patients are tied directly to an additional active protocol directed at the assessment of B220 expression on human lymphocytes. The relative deficiency in CD4/CD25 T cells that we have identified has resulted in the initiation of functional studies directed at this T cell subpopulation to assess if the immunophenotypic findings represent a functional defect in immunoregulatory T cells that could explain the genotype phenotype disparity in families with ALPS type 1a.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ASSESSMENT OF PERIPHERAL BLOOD EOSINOPHILS
  • 批准号:
    6289480
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    thomas a fleisher
  • 依托单位:
Assessment of Peripheral Blood Monocytes in Patients with Recurrent Mycobacterial
  • 批准号:
    6103714
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    thomas a fleisher
  • 依托单位:
Assessment of Hydrogen Peroxide Generation in Neutrophils
  • 批准号:
    6431837
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    thomas a fleisher
  • 依托单位:
ASSESSMENT OF MEMORY B CELLS IN IMMUNE DISORDERS
  • 批准号:
    6414335
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    thomas a fleisher
  • 依托单位: