ASSESSMENT OF PERIPHERAL BLOOD EOSINOPHILS

外周血嗜酸性粒细胞的评估

• 批准号: 6289480
• 负责人: thomas a fleisher
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289480
• 关键词: blood disorder diagnosis; blood tests; clinical research; eosinophil; eosinophilia; human subject; immunologic assay /test; monoclonal antibody

An extensive panel of monoclonal antibodies is being used to evaluate and characterize eosinophils in normal subjects and patients with eosinophilia resulting from infection or other causes. The data are being generated using a novel gating approach that was developed by Dr. Nutmans lab. These data are continuing to be collected for evidence of changes in peripheral eosinophils as a consequence of eosinophil mobilization and disease, in particular the hyper eosinophilia. They will be used to evaluate an extended pedigree with familial hyper eosinophilia. This project is terminated.

一组广泛的单克隆抗体被用于评估和表征正常受试者和感染或其他原因导致的嗜酸性粒细胞增多症患者的嗜酸性粒细胞。这些数据是使用Nutmans博士实验室开发的一种新型门控方法生成的。继续收集这些数据，作为嗜酸性粒细胞动员和疾病（特别是高嗜酸性粒细胞增多）导致的外周嗜酸性粒细胞变化的证据。它们将用于评价家族性高嗜酸性粒细胞增多症的扩展家系。这个项目被终止了。