Assessment of Peripheral Blood Monocytes in Patients with Recurrent Mycobacterial
Assessment of Peripheral Blood Monocytes in Patients with Recurrent Mycobacterial
批准号:
6103714
负责人:
thomas a fleisher
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
单核细胞的特征在于
CD 40、CD 80、CD 86、CD 120 b和γ-CD的表达水平
干扰素受体α链。这些研究确定了两个
γ干扰素受体α链缺陷患者,和
目前正在积极研究这一缺陷的分子水平。在
此外,1例干扰素γ受体β链
在分子水平上也对缺陷进行了表征。作为
这些研究的结果,细胞内流式细胞术
一种评价STAT蛋白磷酸化的方法,
开发和验证。这种方法可以适用于
各种各样的活化相关蛋白质改变。这条线
目前正在进行调查。
英文摘要
Monocytes are being characterized for the
expression levels of CD40, CD80, CD86, CD120b, and the gamma
interferon receptor alpha chain. These studies have identified two
patients with gamma interferon receptor alpha chain deficiency, and
the molecular level of this defect is being actively examined. In
addition, one patient with interferon gamma receptor beta chain
deficiency also has been characterized at the molecular level. As a
consequence of these studies, an intracellular flow cytometric
method for evaluating STAT protein phosphorylation has been
developed and validated. This approach can be adapted for use for
a wide variety of activation associated protein alterations. This line
of investigation currently is being pursued.
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会议论文
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财政年份:--
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财政年份:--
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负责人:thomas a fleisher
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依托单位:
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批准号:7004946
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项目类别:
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资助金额:$0.0万
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