Assessment of Peripheral Blood Monocytes in Patients with Recurrent Mycobacterial

单核细胞的特征是 CD40、CD80、CD86、CD120b和γ的表达水平 干扰素受体阿尔法链。这些研究已经确定了两个 患有干扰素受体α链缺陷的患者，以及 这一缺陷的分子水平正在被积极地检查。在……里面 此外，一名患有干扰素伽马受体β链的患者 在分子水平上也有缺陷的特征。作为一名 这些研究的结果是，细胞内流式细胞仪 评估STAT蛋白磷酸化的方法已被 开发和验证。此方法可用于以下方面 各种各样的激活相关蛋白改变。这条线 目前正在进行调查。

Monocytes are being characterized for the expression levels of CD40, CD80, CD86, CD120b, and the gamma interferon receptor alpha chain. These studies have identified two patients with gamma interferon receptor alpha chain deficiency, and the molecular level of this defect is being actively examined. In addition, one patient with interferon gamma receptor beta chain deficiency also has been characterized at the molecular level. As a consequence of these studies, an intracellular flow cytometric method for evaluating STAT protein phosphorylation has been developed and validated. This approach can be adapted for use for a wide variety of activation associated protein alterations. This line of investigation currently is being pursued.