ASSESSMENT OF LYMPHOCYTES IN PATIENTS WITH AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROM

自身免疫性淋巴细胞增殖综合征患者的淋巴细胞评估

• 批准号: 6289482
• 负责人: thomas a fleisher
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289482
• 关键词: B lymphocyte; T lymphocyte; autoimmune disorder; clinical research; genetic disorder; human subject; immunopathology diagnosis; lymphocyte proliferation; surface antigens

An extensive evaluation flow cytometric evaluation continues of patients with autoimmune lymphoproliferative syndrome (ALPS) and their extended-family members. The evaluation is based on characterization of the expanded double negative T-cell and B-cell populations. To date, the double negative T-cells have been demonstrated to be alpha beta TcR, CD57+, HLA-DR+, and CD45RA+. This study has been extended to characterize the double negative T cells more completely including gamma-delta TcR T cells in all ALPS patients. In addition, expanded characterization of the B cells in these patients has also been initiated.

一个广泛的评估流式细胞术的评估继续与自身免疫性淋巴增生综合征（ALPS）患者及其大家庭成员。该评价基于扩增的双阴性T细胞和B细胞群的表征。迄今为止，双阴性T细胞已被证明是α β TcR、CD 57+、HLA-DR+和CD 45 RA+。这项研究已经扩展到更完整地表征双阴性T细胞，包括所有ALPS患者中的γ-δ TcR T细胞。此外，还开始对这些患者的B细胞进行扩展表征。