ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA

阻塞性睡眠呼吸暂停中舌肌的激活

• 批准号: 6721350
• 负责人: DOMINIQUE M DURAND
• 金额: $ 19.13万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6721350
• 关键词: bioengineering /biomedical engineering; decerebration; dogs; electrostimulus; fiber optics; hypoglossal nerve; medical implant science; neuroimaging; neuromuscular stimulator; respiratory airflow disorder; sleep apnea; technology /technique development; tongue

DESCRIPTION:(adapted from applicant's abstract) This project aims to develop an experimental therapy for obstructive sleep apnea (OSA) using electrical stimulation of the hypoglossal nerve. The PI proposes to use a multi-channel stimulation technique for selective activation of portions of the hypoglossal nerve to activate individual tongue muscles selectively. Such stimulation might increase control over the tongue muscles and improve efficiency for electrical stimulation to remove pharyngeal obstruction. There are 3 aims to be tested in dogs. Aim 1 will determine the maximum muscle selectivity that can be obtained with a multi-contact electrode on the hypoglossal nerve. Aim 2 will evaluate the mechanical dilation of the airways due to selective stimulation. Aim 3 will determine the optimum electrode geometries and stimulation paradigms for airway dilation in chronic dogs. It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA.

描述：（改编自申请人摘要） 本项目旨在开发一种阻塞性睡眠的实验性治疗方法 使用舌下神经的电刺激治疗呼吸暂停（OSA）。的PI 提出使用多通道刺激技术用于选择性激活 舌下神经的一部分来激活个别的舌头肌肉 选择性地。这种刺激可能会增加对舌头肌肉的控制 并提高电刺激去除咽部的效率 梗阻有3个目标在犬中进行测试。目标1将决定 多触点电极可获得最大的肌肉选择性 在舌下神经上目的2将评价机械扩张的 由于选择性刺激，目标3将确定最佳方案 用于慢性气道扩张的电极几何形状和刺激范例 狗预计的实验描绘和验证 这些方法将导致设计神经假体装置， 阻塞性睡眠呼吸暂停综合症的治疗。

项目成果

Effects of selective hypoglossal nerve stimulation on canine upper airway mechanics.

选择性舌下神经刺激对犬上气道力学的影响。

• DOI: 10.1152/japplphysiol.00652.2004
• 发表时间: 2005
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Yoo,PaulB;Durand,DominiqueM
• 通讯作者: Durand,DominiqueM

Selective stimulation of the canine hypoglossal nerve using a multi-contact cuff electrode.

使用多接触袖带电极选择性刺激犬舌下神经。

• DOI: 10.1023/b:abme.0000019170.74375.fb
• 发表时间: 2004
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Yoo,PaulB;Sahin,Mesut;Durand,DominiqueM
• 通讯作者: Durand,DominiqueM

Selective recording of the canine hypoglossal nerve using a multicontact flat interface nerve electrode.

使用多接触平面接口神经电极选择性记录犬舌下神经。

• DOI: 10.1109/tbme.2005.851482
• 发表时间: 2005
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Yoo,PaulB;Durand,DominiqueM
• 通讯作者: Durand,DominiqueM