CLINICAL CORE

临床核心中心是该中心的业务中心。因此，它对于收集满足中心科学使命以及实现每个模块的研究目标所需的数据是不可或缺的。及时、准确和完整的数据收集是一项至关重要的高度优先的任务。在履行这一首要责任时，临床核心对所有受试者(先证者、配偶、子女)进行诊断确定，监督所有 研究计划，并指导生物标本的收集和样本分发到不同的实验室。 此外，临床核心对中心所有人类受试者和数据收集程序进行监督，以确保符合匹兹堡大学IRB和NIH的规定。

The Clinical Core is the operational hub of the Center. It is thus integral to collecting the data necessary for satisfying the Center's scientific mission as well as achieving the research goals of each module. Timely, accurate and complete data collection is an essential highly prioritized task. In fulfilling this overarching responsibility, the Clinical Core conducts the diagnostic ascertainment of all subjects (probands, spouses, children), oversees implementation of all the research protocols, and directs biological specimen collection and distribution of the samples to various laboratories. In addition, the Clinical Core exercises oversight of all Center human subject and data collection procedures pertinent to ensuring compliance with the University Pittsburgh IRB and NIH regulations.