Psychopathology in Pharmacotherapy of AUD/MDD Teens

描述(由申请人提供)：涉及青少年酒精使用障碍(AUD)研究的临床试验和临床指导远远落后于成人。这项关于以患者为导向的研究的职业中期研究人员奖的提案描述了以患者为导向的研究、指导和职业发展方面的职业计划，该领域涉及患有AUD和共病的严重抑郁症(MDD)的青少年临床试验。申请人以前在对患有AUD/MDD的成年人进行药物治疗研究方面表现出专业知识。这一拟议奖项的职业发展部分将寻求将申请者以最佳方式进行和解释药物治疗研究的能力扩展到那些涉及青少年AUD人群的研究。这一目标将通过加强申请者在发展精神病理学和特定的高级统计技术方面的背景来实现。这种培训将使申请者成为与这一重要但未得到充分研究的群体一起工作的受训者的更有效的导师。这项工作还将加强申请人对抑郁症状的临床改善与治疗期间患有AUD/MDD青少年之间的酒精使用之间的关系的了解。这项K24奖项中建议的临床研究与一项涉及氟西汀治疗患有AUD/MDD(R01 AA13370)的青少年的双盲、安慰剂对照研究有关，该研究现已进入第三年。 这项申请中提出的研究试图通过阐明饮酒和抑郁症状改善之间关系的本质，将这项资助的工作扩展到青少年中。这一奖励将允许申请者减少各种临床、管理和研究职责，以便专注于患有澳门氏症的青少年人口。职业生涯计划中最大的部分是指导以患者为导向的研究中的受训人员，这些研究涉及患有AUD的青少年。这不仅有利于申请者的教育发展，还将解决该领域研究人员匮乏的问题。

DESCRIPTION (provided by applicant): Clinical trials and clinical mentoring involving studies of adolescents with alcohol use disorders (AUD) lag considerably behind those for adults. This proposal for a Mid-Career Investigator Award in Patient-Oriented Research describes a career plan in patient-oriented research, mentorship, and career development in the area of clinical trials involving adolescents with AUD and comorbid major depression (MDD). The applicant has previously demonstrated expertise in conducting pharmacotherapy studies involving adults with comorbid AUD/MDD. The Career Development portion of this proposed award will seek to extend the applicant's ability to optimally conduct and interpret pharmacotherapy studies to those involving adolescent AUD populations. This goal would be accomplished by strengthening the applicant's background in developmental psychopathology and specified advanced statistical techniques. This training would make the applicant a more effective mentor for trainees working with this important but understudied population. This work would also enhance the applicant's knowledge of the relationship between clinical improvements in depressive symptoms and alcohol use among comorbid AUD/MDD adolescents during treatment. The clinical study proposed in this K24 award is associated with a double-blind, placebo-controlled study involving fluoxetine in adolescents with comorbid AUD/MDD (R01 AA13370), now in its third year. Research proposed in this application seeks to extend this funded work with adolescents by elucidating the nature of the relationship between improvement both in drinking and in depressive symptoms. This award would allow the applicant to curtail various clinical, administrative, and research duties in order to focus on adolescent populations with AUD. The largest part of the career plan is the mentoring of trainees in patient-oriented research involving adolescents with AUD. This will not only benefit the applicant's educational development, but will also address the paucity of researchers in this area.