STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAIN

耳蜗核颗粒细胞域的研究

• 批准号: 6767860
• 负责人: DAVID K. RYUGO
• 金额: $ 30.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6767860
• 关键词: auditory cortex; auditory discrimination; auditory nuclei; auditory stimulus; axon; brain electrical activity; brain mapping; cats; cerebellum; electron microscopy; granule cell; immunocytochemistry; injection /infusion; laboratory rat; light microscopy; mesencephalon; molecular site; neural information processing; neuronal transport; neurons; pons; radiotracer; sensorimotor system; sound frequency; synaptic vesicles

DESCRIPTION: (Adapted from the Investigator's Abstract) Our long-term goal is to understand neuronal mechanisms that underlie hearing. All acoustic information from the environment enters the brain via the auditory nerve and synpases in the cochlear nucleus. The cochlear nucleus in turn gives rise to the ascending pathways. The perception of sound is normally attributed to processing by these ascending pathways, but data are accumulating that stimulus context also plays a major role. That is, the meaning of a sound depends not only on spectral and temporal characteristics, but also on the past history and behavioral state of the animal. This contextual information could be provided by descending auditory pathways and neural systems not traditionally considered "auditory." In this application, we plan to study the interface between these ascending and descending systems. We propose that the granule cell domain of the cochlear nucleus represents a key site for the integration of multimodal influences. Preliminary data reveal that, in addition to descending auditory projections, there are somatosensory, vestibular and motor inputs to the granular cell domain. For the present application, we will apply anterograde and retrograde tract tracing methods to identify these neurons and their circuits, immunocytochemical staining procedures to reveal the chemistry of the different neurons and their terminals, and electrophysiological recording techniques to characterize the response properties of neurons projecting to this region. The data from this research will provide new knowledge on the synpatic organization of the highly integrative structure in the auditory system, and yield insights into how diverse neural systems shape the coding process for hearing.

描述：（改编自研究者摘要）我们的长期目标是