Proposal for a Chicago-CRIC Clinical Center

芝加哥-CRIC 临床中心提案

• 批准号: 6946285
• 负责人: JAMES P. LASH
• 金额: $ 5.47万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946285
• 关键词: blood chemistry; cardiovascular disorder; cardiovascular imaging /visualization; chronic renal failure; clinical research; cooperative study; disease /disorder proneness /risk; epidemiology; glomerular filtration rate; human morbidity; human mortality; human subject; longitudinal human study; noninvasive diagnosis; urinalysis

DESCRIPTION(provided by applicant): Individuals with chronic renal insufficiency (CRI) represent a large and growing segment of our population, with much of the recent growth fueled by the increased incidence of diabetes. The adverse impact of cardiovascular disease (CVD) in the end stage renal disease (ESRD) population has its beginnings earlier, during the course of CRI, but associated risk factors have not been completely characterized. The overlap between several CVD and renal disease risk factors suggests interactions between CRI and CVD that are not completely understood. The primary goals of the Prospective Cohort Study of Chronic Renal Insufficiency (CRIC) are to determine the risk factors for accelerated decline in renal function and to determine the incidence of, and identify risk factors for, cardiovascular disease in the CRI population. The proposed Chicago-CRIC Consortium is a group of closely tied institutions with a history of previous collaborations, serving a geographically compact and densely populated area, serving an adult patient population of several million among which an estimated 96,000 have CRI with GFRs in the range of 30-70 ml/min/1.73m2. Using our previously effective strategies in recruiting for the NIH-sponsored African American Study of Kidney Disease and Hypertension (AASK) and HEMO trials, we will recruit and retain 500 men and women with chronic renal insufficiency (CRI) from patients served by Chicago-CRIC institutions. The Chicago-CRIC Clinical Center will provide yearly Comprehensive Visits for six to seven years, which will include 125-iothalamate GFRs, blood pressure measurements, anthropometrics, urine and blood testing, and cardiovascular imaging (electron beam tomograpy [EBT], echocardiography, and carotid ultrasound). In addition, we will provide regular morbidity and mortality follow-up, which will include the tracking and classification of renal and cardiovascular endpoints. The strengths of the Chicago-CRIC Clinical Center are the established history of collaboration between the member institutions, our experience as investigators in two previous large NIH multicenter clinical studies involving renal patients (AASK and HEMO), the utilization of an existing, N1H-funded General Clinical Research Center (GCRC) for all study visits, and our ability to access databases containing a very large CRI population.

描述（由申请人提供）： 患有慢性肾功能不全 (CRI) 的个体占很大一部分 我们的人口不断增长，最近的增长大部分是由 糖尿病发病率增加。心血管疾病的不利影响 (CVD) 终末期肾病 (ESRD) 人群已开始 早些时候，在 CRI 过程中，但相关的危险因素尚未被确定 完全表征。几种心血管疾病和肾脏疾病之间的重叠 风险因素表明 CRI 和 CVD 之间的相互作用并不完全 明白了。慢性肾病前瞻性队列研究的主要目标 不足（CRIC）是为了确定加速衰退的风险因素 肾功能并确定发病率并确定危险因素 CRI 人群中的心血管疾病。拟议的芝加哥-CRIC 联盟是一组紧密联系的机构，具有以前的历史 合作，服务于地理紧凑、人口稠密的地区， 为数百万成年患者提供服务，其中估计 96,000 人的 CRI 和 GFR 在 30-70 ml/min/1.73m2 范围内。使用我们的 以前在 NIH 赞助的非洲招募中有效的策略 美国肾脏病和高血压研究 (AASK) 和 HEMO 试验，我们 将招募并保留 500 名患有慢性肾功能不全的男性和女性 (CRI) 来自芝加哥 CRIC 机构服务的患者。芝加哥-CRIC 临床中心每年将为六至七人提供全面就诊 年，其中包括 125-碘酞酸盐 GFR、血压测量、 人体测量学、尿液和血液检测以及心血管成像（电子 束断层扫描 [EBT]、超声心动图和颈动脉超声）。此外， 我们将提供定期的发病率和死亡率随访，其中包括 肾脏和心血管终点的跟踪和分类。这 芝加哥-CRIC 临床中心的优势在于其悠久的历史 成员机构之间的合作，我们作为研究人员的经验 之前两项涉及肾脏病患者的大型 NIH 多中心临床研究 （AASK 和 HEMO），利用现有的 N1H 资助的普通临床 研究中心 (GCRC) 提供所有研究访问，以及我们访问的能力 包含大量 CRI 群体的数据库。