Inner Ear Consortium (CORE CENTER)

内耳联盟（核心中心）

• 批准号: 6798195
• 负责人: DWAYNE D SIMMONS
• 金额: $ 35.86万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-26 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798195
• 关键词: biomedical facility; labyrinth

DESCRIPTION (provided by applicant): We are requesting funds to support a recently constituted Inner Ear Core Consortium designed to enhance exiting research programs and to promote cooperative interactions among 18 scientists at Central institute for the Deaf (CID), Washington University Medical School (WUMS), and St. Louis University (SLU). This consortium consists of an administrative Core Center, three research-oriented core facilities (Digital Imaging Core Electron Microscopy Core, and Gene Expression Core), and one service-oriented core facility (Electronic Services Core). These core facilities are physically located in a new CID research building, recently completed and occupied, immediately adjacent to the south end of the WUMS campus. The scientists in the Inner Ear Consortium have research backgrounds in anatomy, biochemistry, cell biology, developmental biology, molecular biology, molecular genetics, and physiology. These scientists have primary appointments in the Fay and Carl Simons Center for Biology of Hearing and Deafness, one of two centers of excellence at CID, the Departments of Otolaryngology, Anatomy and Neurobiology, Anesthesiology, Molecular Biology and Pharmacology at WUMS, and the Department of Anatomy and Neurobiology at SLU. The research programs of these scientists address crucial issues in the development, function, and regeneration of sensory receptors and their neuronal innervation in the vertebrate inner ear. The Inner Ear Consortium maintains expensive common equipment, supports the common needs of inner ear scientists for digital imaging, ultrastructural analysis, and studies of gene expression. It encourages research collaborations that cross existing research programs by promoting interactions among (1) researchers who study the morphology and physiology of the normal, developing, and regenerating inner ear, (2) researchers who study the inner ear on systemic, cellular, and subcellular levels, and (3) researchers who study the auditory and vestibular systems. It promotes the use of mutant and transgenic animal models and trains inner ear scientists in new research techniques, fostering the transfer of these techniques among inner ear laboratories. The Inner Ear Consortium also provides limited assistance for pilot projects, especially those that advance existing scientific programs, involve multiple investigators, or promise to provide new techniques of general interest to inner ear scientists. Finally, it enhances the research training that consortium members provide to residents and medical students in the Department of Otolaryngology and graduate students in the Departments of Speech and Hearing Sciences at CID and the Division of Biology and Biological Sciences at WUMS.

描述（由申请人提供）：我们要求资金支持 最近构成内耳核心财团，旨在增强出口 研究计划并促进18位科学家之间的合作互动 华盛顿大学医学院聋人中央研究所（CID） （Wums）和圣路易斯大学（SLU）。这个财团由 行政核心中心，三个面向研究的核心设施（数字 成像核心电子显微镜核心和基因表达核心），一个 面向服务的核心设施（电子服务核心）。这些核心设施 物理位于新的CID研究大楼，最近完成， 被占领，紧邻Wums校园的南端。这 内耳联盟中的科学家在解剖学方面具有研究背景， 生物化学，细胞生物学，发育生物学，分子生物学，分子 遗传学和生理学。这些科学家在Fay中有主要任命 和卡尔·西蒙斯（Carl Simons）的听力和耳聋生物学中心，这是两个中心之一 CID卓越，耳鼻喉科，解剖学和 神经生物学，麻醉学，分子生物学和药理学和药理学，以及 SLU的解剖学和神经生物学系。研究计划 这些科学家解决了开发，功能和 感觉受体的再生及其神经神经支配 脊椎动物内耳。 内耳财团维护昂贵的普通设备，支持 内耳科学家对数字成像，超微结构的共同需求 分析和基因表达的研究。它鼓励研究合作 通过促进（1）之间的互动来跨越现有的研究计划 研究正常，发展，发展的研究人员 （2）研究全身性内耳的研究人员， 细胞和亚细胞水平，以及（3）研究听觉和 前庭系统。它促进使用突变和转基因动物模型 并培训内耳科学家的新研究技术，促进 这些技术在内耳实验室之间的转移。内耳 财团还为试点项目提供有限的帮助，尤其是那些 这项推进了现有的科学计划，涉及多个研究人员或 承诺向内耳科学家提供一般兴趣的新技术。 最后，它增强了财团成员提供给的研究培训 耳鼻喉科和研究生系的居民和医学生 CID的演讲和听力科学系的学生和 WUMS生物学和生物科学系。