Inner Ear Consortium (CORE CENTER)

描述(由申请人提供)：我们正在申请资金，以支持 最近成立的内耳核心财团旨在加强退出 研究计划，并促进18名科学家之间的合作互动 华盛顿大学医学院聋人中心(CID) 圣路易斯大学(SLU)。该财团由一个 行政核心中心，三个研究型核心设施(数字 成像核心、电子显微镜核心和基因表达核心)，以及一个 面向服务的核心设施(电子服务核心)。这些核心设施 实际位于一座新的CID研究大楼内，该大楼最近完工 被占领，紧挨着WUMS校园的南端。这个 内耳协会的科学家有解剖学方面的研究背景， 生物化学、细胞生物学、发育生物学、分子生物学、分子 遗传学和生理学。这些科学家在费伊有主要的任命 和卡尔·西蒙斯听力和耳聋生物学中心，这是两个中心之一 在CID，耳鼻咽喉科，解剖学和 WUMS神经生物学、麻醉学、分子生物学和药理学，以及 SLU解剖学和神经生物学系。的研究计划 这些科学家致力于解决发展、功能和 大脑皮层感觉受体的再生及其神经支配 脊椎动物的内耳。 内耳联盟维护昂贵的通用设备，支持 内耳科学家对数字成像、超微结构的共同需求 对基因表达的分析和研究。它鼓励研究合作 通过促进(1)之间的互动来跨越现有的研究计划 研究正常的、发育中的、 和再生内耳，(2)研究内耳系统的研究人员， 细胞和亚细胞水平，以及(3)研究听觉和 前庭系统。它促进突变和转基因动物模型的使用 并对内耳科学家进行新的研究技术培训，促进 这些技术在内耳实验室之间的转移。内耳 财团还为试点项目提供有限的援助，特别是 推进现有的科学计划，涉及多名调查人员，或者 承诺提供内耳科学家普遍感兴趣的新技术。 最后，它加强了联盟成员提供的研究培训 耳鼻咽喉科住院医师和医学生及研究生 CID和CID言语和听力科学系的学生 威斯康星大学生物与生物科学部。

DESCRIPTION (provided by applicant): We are requesting funds to support a recently constituted Inner Ear Core Consortium designed to enhance exiting research programs and to promote cooperative interactions among 18 scientists at Central institute for the Deaf (CID), Washington University Medical School (WUMS), and St. Louis University (SLU). This consortium consists of an administrative Core Center, three research-oriented core facilities (Digital Imaging Core Electron Microscopy Core, and Gene Expression Core), and one service-oriented core facility (Electronic Services Core). These core facilities are physically located in a new CID research building, recently completed and occupied, immediately adjacent to the south end of the WUMS campus. The scientists in the Inner Ear Consortium have research backgrounds in anatomy, biochemistry, cell biology, developmental biology, molecular biology, molecular genetics, and physiology. These scientists have primary appointments in the Fay and Carl Simons Center for Biology of Hearing and Deafness, one of two centers of excellence at CID, the Departments of Otolaryngology, Anatomy and Neurobiology, Anesthesiology, Molecular Biology and Pharmacology at WUMS, and the Department of Anatomy and Neurobiology at SLU. The research programs of these scientists address crucial issues in the development, function, and regeneration of sensory receptors and their neuronal innervation in the vertebrate inner ear. The Inner Ear Consortium maintains expensive common equipment, supports the common needs of inner ear scientists for digital imaging, ultrastructural analysis, and studies of gene expression. It encourages research collaborations that cross existing research programs by promoting interactions among (1) researchers who study the morphology and physiology of the normal, developing, and regenerating inner ear, (2) researchers who study the inner ear on systemic, cellular, and subcellular levels, and (3) researchers who study the auditory and vestibular systems. It promotes the use of mutant and transgenic animal models and trains inner ear scientists in new research techniques, fostering the transfer of these techniques among inner ear laboratories. The Inner Ear Consortium also provides limited assistance for pilot projects, especially those that advance existing scientific programs, involve multiple investigators, or promise to provide new techniques of general interest to inner ear scientists. Finally, it enhances the research training that consortium members provide to residents and medical students in the Department of Otolaryngology and graduate students in the Departments of Speech and Hearing Sciences at CID and the Division of Biology and Biological Sciences at WUMS.