Norwegian Mother /Child Study: Environmental Specimen

挪威母亲和儿童研究是对挪威孕妇及其子女的队列研究。NIEHS正在通过建立一个生物样本储存库来评估环境暴露和对孕妇及其未出生婴儿的健康影响，从而为这一努力做出贡献。截至2003年8月31日，12,512名妇女为研究的NIEHS部分提供了生物样本（血液和尿液）;本财政年度有8177名妇女参加。这些样本是在挪威的41家医院收集的，包括城市中心和北极地区。入学目标是50 000名妇女。按照目前的招募速度，我们预计将有30 000名妇女在怀孕17周时采集血液和尿液样本，以评估环境暴露情况。 在过去的财政年度，我们解决了与样品运输和处理有关的问题。我们与CDC合作，确定了防止尿液样本细菌污染的最佳方法，同时仍保留了未来感兴趣的分析物（苯酚，邻苯二甲酸酯，非持久性农药，砷，汞）。这些数据将用于大型队列研究中的其他研究者，手稿正在准备中。我们正在与挪威研究人员合作，实施质量保证实验和方案，以评估各种参数的储存条件。这将需要大约2年的时间才能完成。我们目前正在设计一项研究，使用NIEHS样本并链接到母亲的问卷数据和医学出生登记数据，以评估常见环境污染物（可能是邻苯二甲酸酯）对健康的影响。

The Norwegian Mother and Child study is a cohort study of pregnant women and their children in Norway. NIEHS is contributing to this effort by creating of a biological specimen repository to evaluate environmental exposures and health effects to pregnant women and their unborn children. As of Aug 31, 2003, 12,512 women had contributed biological samples (blood and urine) for the NIEHS portion of the study; 8177 women were enrolled this fiscal year. These samples have been collected at 41 hospitals across Norway including urban centers and the Arctic regions. The enrollment target is 50,000 women. At the current recruitment rate we anticipate 30,000 women with blood and urine samples collected at 17 weeks gestation to evaluate for environmental exposures. During the past fiscal year, we resolved problems associated with sample shipment and handling. Working with CDC, we identified the optimal means to prevent bacterial contamination of urine samples while still maintaining the analytes of future interest (phenols, phthalates, non-persistent pesticides, arsenic, mercury). These data will be of use to other investigators in large cohort studies and a manuscript is in preparation. In collaboration with Norwegian investigators, we are implementing a quality assurance experiment and protocol to assess storage conditions for a variety of parameters. This will take ~2 years to complete. We are currently designing a study to use the NIEHS samples and link to the questionnaire data from the mother and the Medical Birth Registry data to assess health effects of a common environmental contaminant, probably phthalates.